P11

Modify Date: 2024-09-08 17:04:32

P11 structure	Common Name	P11
	CAS Number	848644-86-0	Molecular Weight	720.78
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₀H₄₈N₁₂O₉	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of P11

HSDVHK-NH2 is an antagonist of the integrin αvβ3-vitronectin interaction, with an IC50 of 1.74 pg/mL (2.414 pM)[1][2].

Name	HSDVHK-NH2

Description	HSDVHK-NH2 is an antagonist of the integrin αvβ3-vitronectin interaction, with an IC50 of 1.74 pg/mL (2.414 pM)[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cytoskeleton >> Integrin
Target	αvβ3:2.74 nM (IC50)
In Vitro	HSDVHK significantly inhibited bFGF-induced cell migration compared to the PBS control group[1]. The Arg-Gly-Asp (RGD)-binding site recognition by HSDVHK-NH2 (P11) is site specific because the HSDVHK-NH2 (P11) is inactive for the complex formation of a denatured form of integrin–vitronectin. HSDVHK-NH2 (P11) shows a strong antagonism against avb3-GRGDSP interaction with an IC50 value of 25.72 nM[2]. HSDVHK-NH2 (P11) inhibits the HUVEC proliferation due to the induction of HUVEC cell death through caspases activations and its mechanism is related with increased p53 expression[3]. Cell Proliferation Assay[3] Cell Line: HUVEC cells. Concentration: 0.1, 1, 10, and 100 μg/mL. Incubation Time: 72 h. Result: Significantly inhibited HUVEC proliferation on denatured collagen-coated plates in a dose-dependent manner.
References	[1]. Yoonsuk Lee, et al. High-throughput screening of novel peptide inhibitors of an integrin receptor from the hexapeptide library by using a protein microarray chip. J Biomol Screen. 2004 Dec;9(8):687-94. [2]. Youngjin Choi, et al. Site-specific inhibition of integrin alpha v beta 3-vitronectin association by a ser-asp-val sequence through an Arg-Gly-Asp-binding site of the integrin. Proteomics. 2010 Jan;10(1):72-80. [3]. Ji-Young Bang, et al. Pharmacoproteomic analysis of a novel cell-permeable peptide inhibitor of tumor-induced angiogenesis. Mol Cell Proteomics. 2011 Aug;10(8):M110.005264.

Molecular Formula	C₃₀H₄₈N₁₂O₉
Molecular Weight	720.78

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: HSDVHK-NH2
Price: Click To Check
Purity: 99.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: HSDVHK-NH2
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Taiwan Oyi peptide Co. Ltd
China
Product Name: P11
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
Delivery: 1 Day
Contact: Vinnie
Email: Jamie@api-made.com

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