Pyocyanine

Modify Date: 2024-01-11 17:27:49

Pyocyanine Structure
Pyocyanine structure
Common Name Pyocyanine
CAS Number 85-66-5 Molecular Weight 210.231
Density 1.24g/cm3 Boiling Point 403.3ºC at 760 mmHg
Molecular Formula C13H10N2O Melting Point N/A
MSDS Chinese USA Flash Point 197.7ºC
Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger

 Use of Pyocyanine


Pyocyanin (Pyocyanine) is a phenazine that is a toxic, quorum sensing (QS)-controlled metabolite produced by P. aeruginosa. Pyocyanin is a redox-active compound and promotes the generation of reactive oxygen species (ROS). Pyocyanin also possesses antibacterial properties and increases fitness in competition with other bacterial species[1].

 Names

Name 5-methylphenazin-1-one
Synonym More Synonyms

 Pyocyanine Biological Activity

Description Pyocyanin (Pyocyanine) is a phenazine that is a toxic, quorum sensing (QS)-controlled metabolite produced by P. aeruginosa. Pyocyanin is a redox-active compound and promotes the generation of reactive oxygen species (ROS). Pyocyanin also possesses antibacterial properties and increases fitness in competition with other bacterial species[1].
Related Catalog
References

[1]. Paulina Castañeda-Tamez, et al. Pyocyanin Restricts Social Cheating in Pseudomonas aeruginosa. Front Microbiol. 2018 Jun 27;9:1348.

 Chemical & Physical Properties

Density 1.24g/cm3
Boiling Point 403.3ºC at 760 mmHg
Molecular Formula C13H10N2O
Molecular Weight 210.231
Flash Point 197.7ºC
Exact Mass 210.079315
PSA 39.83000
LogP 2.35630
Index of Refraction 1.665

 Safety Information

Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H302-H318
Precautionary Statements P280-P305 + P351 + P338
RIDADR NONH for all modes of transport
HS Code 2933990090

 Precursor & DownStream

Precursor  1

DownStream  0

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles47

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PLoS ONE 10(4) , e0124961, (2015)

Oxidative stress enhances inflammation and reduces the effectiveness of corticosteroids, but the inflammatory signalling pathways induced by oxidants remain ill-defined. Phosphorylation of histone 3 a...

Virulence Factors of Pseudomonas aeruginosa Induce Both the Unfolded Protein and Integrated Stress Responses in Airway Epithelial Cells.

PLoS Pathog. 11 , e1004946, (2015)

Pseudomonas aeruginosa infection can be disastrous in chronic lung diseases such as cystic fibrosis and chronic obstructive pulmonary disease. Its toxic effects are largely mediated by secreted virule...

The impact of plant volatiles on bacterial quorum sensing.

Lett. Appl. Microbiol. 60(1) , 8-19, (2015)

Studies describing the use of essential oil constituents as antimicrobial agents have steadily increased; however, some phyto-constituents are often overlooked due to unfavourable minimum inhibitory c...

 Synonyms

Sanasin
Phenazinium, 1-hydroxy-5-methyl-, inner salt
5-methyl-5H-phenazin-1-one
Pyocyanin
1-hydroxy-5-methyl-phenazinium betaine
5-Methylphenazin-5-ium-1-olate
5-methylphenazin-1(5H)-one
Sanazin
1(5H)-phenazinone, 5-methyl-
Pyocyanine
1-hydroxy-5-methylphenazine
Pyrocyanine
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