6-Methoxy-8-nitroquinoline

Modify Date: 2024-01-03 18:52:19

6-Methoxy-8-nitroquinoline Structure
6-Methoxy-8-nitroquinoline structure
Common Name 6-Methoxy-8-nitroquinoline
CAS Number 85-81-4 Molecular Weight 204.182
Density 1.3±0.1 g/cm3 Boiling Point 373.1±27.0 °C at 760 mmHg
Molecular Formula C10H8N2O3 Melting Point 158-160 °C(lit.)
MSDS Chinese USA Flash Point 179.4±23.7 °C
Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Warning

 Names

Name 6-Methoxy-8-nitroquinoline
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 373.1±27.0 °C at 760 mmHg
Melting Point 158-160 °C(lit.)
Molecular Formula C10H8N2O3
Molecular Weight 204.182
Flash Point 179.4±23.7 °C
Exact Mass 204.053497
PSA 67.94000
LogP 1.86
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.646

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VC0365000
CHEMICAL NAME :
Quinoline, 6-methoxy-8-nitro-
CAS REGISTRY NUMBER :
85-81-4
BEILSTEIN REFERENCE NO. :
0168992
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C10-H8-N2-O3
MOLECULAR WEIGHT :
204.20
WISWESSER LINE NOTATION :
T66 BNJ HO1 JNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
100 nmol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 58,11,1978

 Safety Information

Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Warning
Hazard Statements H302 + H312 + H332-H315-H319-H335-H351
Precautionary Statements P261-P280-P305 + P351 + P338
Personal Protective Equipment Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes Xn: Harmful;
Risk Phrases R20/21/22;R36/37/38;R40
Safety Phrases S26-S27-S36/37/39
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS VC0365000
HS Code 2933499090

 Synthetic Route

~40%

6-Methoxy-8-nitroquinoline Structure

6-Methoxy-8-nit...

CAS#:85-81-4

Literature: Wyeth Patent: US2003/32645 A1, 2003 ; US 20030032645 A1

~17%

6-Methoxy-8-nitroquinoline Structure

6-Methoxy-8-nit...

CAS#:85-81-4

Literature: Armer, Richard E.; Barlow, Jacqueline S.; Chopra, Narinder; Dutton, Christopher J.; Greenway, David H.J.; Greenwood, Sean D.W.; Lad, Nita; Shaw, Jonothan; Thompson, Adrian P.; Thong, Kam-Wah; Tommasini, Ivan Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 16 p. 2425 - 2430

~%

6-Methoxy-8-nitroquinoline Structure

6-Methoxy-8-nit...

CAS#:85-81-4

Literature: Zhurnal Obshchei Khimii, , vol. 3, p. 769,776 Archiv der Pharmazie (Weinheim, Germany), , vol. 271, p. 359,364 Chem. Zentralbl., , vol. 105, # II p. 2227 Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), , vol. 9, p. 304,314 Chem. Zentralbl., , vol. 107, # II p. 1543 Journal of Organic Chemistry, , vol. 12, p. 435 Journal of Organic Chemistry, , vol. 13, p. 937

~%

6-Methoxy-8-nitroquinoline Structure

6-Methoxy-8-nit...

CAS#:85-81-4

Literature: Organic Syntheses, , vol. 27, p. 48,52 DE486079 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 16, p. 2684 DE451730 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 15, p. 1429

~%

6-Methoxy-8-nitroquinoline Structure

6-Methoxy-8-nit...

CAS#:85-81-4

Literature: Journal of Organic Chemistry, , vol. 12, p. 435 Journal of Organic Chemistry, , vol. 13, p. 937

~%

6-Methoxy-8-nitroquinoline Structure

6-Methoxy-8-nit...

CAS#:85-81-4

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 16 p. 2425 - 2430

~%

6-Methoxy-8-nitroquinoline Structure

6-Methoxy-8-nit...

CAS#:85-81-4

Literature: Zhurnal Obshchei Khimii, , vol. 3, p. 769,776 Archiv der Pharmazie (Weinheim, Germany), , vol. 271, p. 359,364 Chem. Zentralbl., , vol. 105, # II p. 2227 Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), , vol. 9, p. 304,314 Chem. Zentralbl., , vol. 107, # II p. 1543

~%

Detail
Literature: Journal of the American Chemical Society, , vol. 70, p. 254

 Customs

HS Code 2933499090
Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles2

More Articles
Ring-substituted quinolines as potential anti-tuberculosis agents.

Bioorg. Med. Chem. 12(10) , 2501-8, (2004)

We report in vitro antimycobacterial properties of ring-substituted quinolines (series 1-4) constituting 56 analogues against drug-sensitive and drug-resistant M. tuberculosis H37Rv strains. The most ...

Primaquine-induced hemolytic anemia: formation and hemotoxicity of the arylhydroxylamine metabolite 6-methoxy-8-hydroxylaminoquinoline.

J. Pharmacol. Exp. Ther. 297(2) , 509-15, (2001)

Primaquine is an important antimalarial agent because of its activity against exoerythrocytic forms of Plasmodium spp. However, methemoglobinemia and hemolytic anemia are dose-limiting side effects of...

 Synonyms

6-Methoxy-8-nitroquinoline
Quinoline, 6-methoxy-8-nitro-
MFCD00006802
EINECS 201-633-7