Pyridoxylamine
Modify Date: 2025-08-25 15:49:16
Pyridoxylamine structure
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Common Name | Pyridoxylamine | ||
|---|---|---|---|---|
| CAS Number | 85-87-0 | Molecular Weight | 168.19300 | |
| Density | 1.282g/cm3 | Boiling Point | 460.1ºC at 760 mmHg | |
| Molecular Formula | C8H12N2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 232.1ºC | |
Use of PyridoxylaminePyridoxylamine is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor, to protect against diabetes-induced retinal vascular lesions. |
| Name | pyridoxamine |
|---|---|
| Synonym | More Synonyms |
| Description | Pyridoxylamine is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor, to protect against diabetes-induced retinal vascular lesions. |
|---|---|
| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | Pyridoxylamine (PM), a member of the B6 vitamer family, is a potent scavenger of reactive carbonyls, inhibiting the late stages of glycation reactions that lead to AGE formation[1]. |
| In Vivo | Pyridoxylamine limits the formation of CML and CEL and cross-linking in skin collagen and, ultimately inhibits the development of nephropathy in STZ-diabetic rats. Pyridoxylamine does not appear to function as an antioxidant since it does not prevent lipid peroxidation reactions. At the same time, it does prevent protein modification by products of lipid peroxidation, including inhibiting formation of malondialdehyde and 4-hydroxynonenal adducts on protein in Zucker rats in vivo[1]. |
| References |
| Density | 1.282g/cm3 |
|---|---|
| Boiling Point | 460.1ºC at 760 mmHg |
| Molecular Formula | C8H12N2O2 |
| Molecular Weight | 168.19300 |
| Flash Point | 232.1ºC |
| Exact Mass | 168.09000 |
| PSA | 79.37000 |
| LogP | 0.74690 |
| Index of Refraction | 1.617 |
| InChIKey | NHZMQXZHNVQTQA-UHFFFAOYSA-N |
| SMILES | Cc1ncc(CO)c(CN)c1O |
| HS Code | 2933399090 |
|---|
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Name: pKa (acid-base dissociation constant) as determined by Liao ref: J Chem Info Model 20...
Source: ChEMBL
Target: N/A
External Id: CHEMBL2449006
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Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4513082
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Name: Inhibition of alpha-dicarbonyls-induced advanced glycation end product formation asse...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1040249
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|
Name: S16 Schwann cell PMP22 intronic element firefly luciferase assay
Source: NCGC
Target: peripheral myelin protein 22 [Rattus norvegicus]
External Id: cmt-p4-fluc-fda_regid
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|
Name: qHTS for Inhibitors of Polymerase Kappa
Source: NCGC
Target: DNA polymerase kappa [Homo sapiens]
External Id: PolK100
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|
Name: Cell-based high throughput primary assay to identify activators of GPR151
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL
External Id: GPR151_PHUNTER_AG_LUMI_1536_1X%ACT
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|
Name: SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f...
Source: ChEMBL
Target: Replicase polyprotein 1ab
External Id: CHEMBL4495582
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|
Name: Chan-Lam from Article : "Open science discovery of potent noncovalent SARS-CoV-2 main...
Source: BindingDB
Target: N/A
External Id: BindingDB_11549_1
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Name: Cytotoxicity in human EAhy926 cells assessed as viable cells at 1 mM after overnight ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1040257
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Name: Cytoprotective activity against MG-induced cytotoxicity in human EAhy926 cells assess...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL1040256
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| 2-Methyl-3-hydroxy-4-aminomethyl-5-hydroxymethylpyridine |
| 4-Aminomethyl-5-hydroxy-6-methyl-3-pyridinemethanol |
| pyridoxiamine |
| PyridoxaMine-d4 |
| pyridoxylamine |
| Pyridorin |