Pyridoxylamine
Pyridoxylamine structure
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Common Name | Pyridoxylamine | ||
|---|---|---|---|---|
| CAS Number | 85-87-0 | Molecular Weight | 168.19300 | |
| Density | 1.282g/cm3 | Boiling Point | 460.1ºC at 760 mmHg | |
| Molecular Formula | C8H12N2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 232.1ºC | |
Use of PyridoxylaminePyridoxylamine is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor, to protect against diabetes-induced retinal vascular lesions. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | pyridoxamine |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Pyridoxylamine is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor, to protect against diabetes-induced retinal vascular lesions. |
|---|---|
| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | Pyridoxylamine (PM), a member of the B6 vitamer family, is a potent scavenger of reactive carbonyls, inhibiting the late stages of glycation reactions that lead to AGE formation[1]. |
| In Vivo | Pyridoxylamine limits the formation of CML and CEL and cross-linking in skin collagen and, ultimately inhibits the development of nephropathy in STZ-diabetic rats. Pyridoxylamine does not appear to function as an antioxidant since it does not prevent lipid peroxidation reactions. At the same time, it does prevent protein modification by products of lipid peroxidation, including inhibiting formation of malondialdehyde and 4-hydroxynonenal adducts on protein in Zucker rats in vivo[1]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.282g/cm3 |
|---|---|
| Boiling Point | 460.1ºC at 760 mmHg |
| Molecular Formula | C8H12N2O2 |
| Molecular Weight | 168.19300 |
| Flash Point | 232.1ºC |
| Exact Mass | 168.09000 |
| PSA | 79.37000 |
| LogP | 0.74690 |
| Index of Refraction | 1.617 |
| InChIKey | NHZMQXZHNVQTQA-UHFFFAOYSA-N |
| SMILES | Cc1ncc(CO)c(CN)c1O |
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| HS Code | 2933399090 |
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This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: pKa (acid-base dissociation constant) as determined by Liao ref: J Chem Info Model 20...
Source: ChEMBL
Target: N/A
External Id: CHEMBL2449006
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Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4513082
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Name: Inhibition of alpha-dicarbonyls-induced advanced glycation end product formation asse...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1040249
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Name: S16 Schwann cell PMP22 intronic element firefly luciferase assay
Source: NCGC
Target: peripheral myelin protein 22 [Rattus norvegicus]
External Id: cmt-p4-fluc-fda_regid
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Name: qHTS for Inhibitors of Polymerase Kappa
Source: NCGC
Target: DNA polymerase kappa [Homo sapiens]
External Id: PolK100
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Name: Cell-based high throughput primary assay to identify activators of GPR151
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL
External Id: GPR151_PHUNTER_AG_LUMI_1536_1X%ACT
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Name: SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f...
Source: ChEMBL
Target: Replicase polyprotein 1ab
External Id: CHEMBL4495582
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Name: Chan-Lam from Article : "Open science discovery of potent noncovalent SARS-CoV-2 main...
Source: BindingDB
Target: N/A
External Id: BindingDB_11549_1
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Name: Cytotoxicity in human EAhy926 cells assessed as viable cells at 1 mM after overnight ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1040257
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Name: Cytoprotective activity against MG-induced cytotoxicity in human EAhy926 cells assess...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL1040256
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 2-Methyl-3-hydroxy-4-aminomethyl-5-hydroxymethylpyridine |
| 4-Aminomethyl-5-hydroxy-6-methyl-3-pyridinemethanol |
| pyridoxiamine |
| PyridoxaMine-d4 |
| pyridoxylamine |
| Pyridorin |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the LogP of pyridoxamine? |
| A: LogP of pyridoxamine is 0.74690. |
| Q: What is the boiling point of pyridoxamine? |
| A: Boiling point of pyridoxamine is 460.1ºC at 760 mmHg. |
| Q: What is the CAS number of pyridoxamine? |
| A: CAS number of pyridoxamine is 85-87-0. |
| Q: What is the polar surface area (PSA) of pyridoxamine? |
| A: Polar surface area (PSA) of pyridoxamine is 79.37000. |
| Q: What is the molecular formula of pyridoxamine? |
| A: Molecular formula of pyridoxamine is C8H12N2O2. |
| Q: What is the molecular weight of pyridoxamine? |
| A: Molecular weight of pyridoxamine is 168.19300. |
| Q: What is the English name of pyridoxamine? |
| A: The English name of pyridoxamine is pyridoxamine. |
| Q: What are the uses of pyridoxamine? |
| A: Main uses of pyridoxamine: Pyridoxylamine is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor, to protect against diabetes-induced retinal vascular lesions. |
| Q: What is the InChIKey of pyridoxamine? |
| A: InChIKey of pyridoxamine is NHZMQXZHNVQTQA-UHFFFAOYSA-N. |
| Q: What English synonyms does pyridoxamine have? |
| A: English synonyms of pyridoxamine: 2-Methyl-3-hydroxy-4-aminomethyl-5-hydroxymethylpyridine, 4-Aminomethyl-5-hydroxy-6-methyl-3-pyridinemethanol, pyridoxiamine, PyridoxaMine-d4, pyridoxylamine, Pyridorin. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |