SAMT-247

Modify Date: 2024-01-08 11:31:07

SAMT-247 structure	Common Name	SAMT-247
	CAS Number	850715-59-2	Molecular Weight	266.32
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₂H₁₄N₂O₃S	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS07	Signal Word	Warning

Use of SAMT-247

SAMT-247 is a microbicide that selectively inactivate the viral nucleocapsid protein NCp7, causing zinc ejection and preventing RNA encapsidation. SAMT-247 shows good antiviral activity[1][2].

Name	Ethanethioic acid, S-[2-[[(3-amino-3-oxopropyl)amino]carbonyl]phenyl] ester

Description	SAMT-247 is a microbicide that selectively inactivate the viral nucleocapsid protein NCp7, causing zinc ejection and preventing RNA encapsidation. SAMT-247 shows good antiviral activity[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	HIV-1IIIB:0.6 μM (EC50)
In Vitro	SAMT-247 通过共价修饰 Gag 多聚蛋白[2]。 SAMT-247 在被 HIV-1IIIB 感染的 CEM-SS 细胞中显示出 EC50 为 0.6 μM 的抗病毒活性。SAMT-247 显示出较低的细胞毒性(TC50 > 100 μM)[2]。
In Vivo	含有 1% SAMT-247 的凝胶配方保护了六只恒河猴中的五只免受 CCR5(R5)-趋向性 SHIV 阴道感染[3]。
References	[1]. Helmold Hait S, et al. An SAMT-247 Microbicide Provides Potent Protection against Intravaginal Simian Immunodeficiency Virus Infection of Rhesus Macaques, whereas an Added Vaccine Component Elicits Mixed Outcomes. J Immunol. 2020 Jun 15;204(12):3315-3328. [2]. Miller Jenkins LM, et al. Small-molecule inactivation of HIV-1 NCp7 by repetitive intracellular acyl transfer. Nat Chem Biol. 2010 Dec;6(12):887-9. [3]. Cheng-Mayer C, et al. Delay of simian human immunodeficiency virus infection and control of viral replication in vaccinated macaques challenged in the presence of a topical microbicide. AIDS. 2011 Sep 24;25(15):1833-41.

Molecular Formula	C₁₂H₁₄N₂O₃S
Molecular Weight	266.32
Exact Mass	266.07300
PSA	114.56000
LogP	2.02160

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
RIDADR	NONH for all modes of transport

Delay of simian human immunodeficiency virus infection and control of viral replication in vaccinated macaques challenged in the presence of a topical microbicide.

AIDS 25(15) , 1833-41, (2011)

Development of an effective vaccine or topical compound to prevent HIV transmission remains a major goal for control of the AIDS pandemic. Using a nonhuman primate model of heterosexual HIV-1 transmis...

SAMT-247

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