Necrostatin 2 (S enantiomer) structure
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Common Name | Necrostatin 2 (S enantiomer) | ||
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CAS Number | 852391-20-9 | Molecular Weight | 277.70600 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C13H12ClN3O2 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of Necrostatin 2 (S enantiomer)Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.IC50 Value: 50 nM (EC50) [1]Target: TNF-alphaNecrostatin 2 is a potent in vitro necroptosis inhibitors (exemplified by 1, EC50-0.05 uM) that also were efficacious in an animal model of ischemic stroke. Many Necroptosis inhibitor derivatives are designed for researchers.Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-a. 5-(1H-Indol-3-ylmethyl)-2-thiohydantoins and 5-(1H-indol-3-ylmethyl)hydantoins were found to be potent necroptosis inhibitors (called necrostatins). |
Name | 2,4-Imidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-, (5S) |
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Synonym | More Synonyms |
Description | Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.IC50 Value: 50 nM (EC50) [1]Target: TNF-alphaNecrostatin 2 is a potent in vitro necroptosis inhibitors (exemplified by 1, EC50-0.05 uM) that also were efficacious in an animal model of ischemic stroke. Many Necroptosis inhibitor derivatives are designed for researchers.Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-a. 5-(1H-Indol-3-ylmethyl)-2-thiohydantoins and 5-(1H-indol-3-ylmethyl)hydantoins were found to be potent necroptosis inhibitors (called necrostatins). |
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Related Catalog | |
References |
Molecular Formula | C13H12ClN3O2 |
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Molecular Weight | 277.70600 |
Exact Mass | 277.06200 |
PSA | 65.20000 |
LogP | 2.18070 |
Storage condition | 2-8℃ |
Necrostatin 2 (S enantiomer) |
Necrostatin 2 S enantiomer |