5,7,3',4'-Tetramethoxyflavone

Modify Date: 2026-07-06 20:13:57

5,7,3',4'-Tetramethoxyflavone Structure
5,7,3',4'-Tetramethoxyflavone structure
Common Name 5,7,3',4'-Tetramethoxyflavone
CAS Number 855-97-0 Molecular Weight 342.34300
Density 1.243g/cm3 Boiling Point 528.8ºC at 760 mmHg
Molecular Formula C19H18O6 Melting Point 195-197°C
MSDS N/A Flash Point 233.9ºC

 Use of 5,7,3',4'-Tetramethoxyflavone


5,7,3',4'-Tetramethoxyflavone, one of the major polymethoxyflavones (PMFs) isolated from M. exotica, possesses various bioactivities, including anti-fungal, anti-malarial, anti-mycobacterial, and anti-inflammatory activities. 5,7,3',4'-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling[1].

 Names

Name 2-(3,4-dimethoxyphenyl)-5,7-dimethoxychromen-4-one
Synonym More Synonyms

 5,7,3',4'-Tetramethoxyflavone Biological Activity

Description 5,7,3',4'-Tetramethoxyflavone, one of the major polymethoxyflavones (PMFs) isolated from M. exotica, possesses various bioactivities, including anti-fungal, anti-malarial, anti-mycobacterial, and anti-inflammatory activities. 5,7,3',4'-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling[1].
Related Catalog
References

[1]. Wu L, et al. 5,7,3',4'-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling in vivo and in vitro. Biochem Biophys Res Commun. 2014 Sep 26;452(3):682-8.

 Chemical & Physical Properties

Density 1.243g/cm3
Boiling Point 528.8ºC at 760 mmHg
Melting Point 195-197°C
Molecular Formula C19H18O6
Molecular Weight 342.34300
Flash Point 233.9ºC
Exact Mass 342.11000
PSA 67.13000
LogP 3.49440
Index of Refraction 1.574
InChIKey CLXVBVLQKLQNRQ-UHFFFAOYSA-N
SMILES COc1cc(OC)c2c(=O)cc(-c3ccc(OC)c(OC)c3)oc2c1

 Safety Information

Safety Phrases S22-S24/25
HS Code 2932999099

 Synthetic Route

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 5,7,3',4'-TetramethoxyflavoneBioassay

View more

Name: Induction of adipogenesis in mouse 3T3L1 cells assessed as increase in triglyceride l...
Source: ChEMBL
Target: 3T3-L1
External Id: CHEMBL1777107
Name: Cytotoxicity against mouse RAW264.7 cells by MTT assay
Source: ChEMBL
Target: RAW264.7
External Id: CHEMBL4029933
Name: Induction of adipogenesis in mouse 3T3L1 cells assessed as increase in triglyceride l...
Source: ChEMBL
Target: 3T3-L1
External Id: CHEMBL1777106
Name: Cytotoxicity against LPS-stimulated mouse RAW264.7 cells assessed as cell viability a...
Source: ChEMBL
Target: RAW264.7
External Id: CHEMBL4029931
Name: Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimu...
Source: ChEMBL
Target: RAW264.7
External Id: CHEMBL4029932
Name: Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimu...
Source: ChEMBL
Target: RAW264.7
External Id: CHEMBL4029930
Name: Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimu...
Source: ChEMBL
Target: RAW264.7
External Id: CHEMBL4029928
Name: Inhibition of NF-kappaB activation expressed in HCT116 cells assessed as inhibition o...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1839570
Name: Induction of adipogenesis in mouse 3T3L1 cells assessed as increase in triglyceride l...
Source: ChEMBL
Target: 3T3-L1
External Id: CHEMBL1777105
Name: Induction of adipogenesis in mouse 3T3L1 cells assessed as increase in triglyceride l...
Source: ChEMBL
Target: 3T3-L1
External Id: CHEMBL1777104
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 Synonyms

Luteolin tetramethyl ether
Tetramethoxyluteolin
5,7,3',4'-Tetramethylluteolin
3',4',5,7-Tetramethyl-luteolin
5,7,3',4'-tetramethoxyflavone
MFCD00017558
Tetramethylluteolin
3',4',5,7-Tetramethoxyflavone
5,7,3'-trimethoxy 4'-hydroxyflavone
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