PSN632408
Modify Date: 2024-01-04 13:13:03
PSN632408 structure
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Common Name | PSN632408 | ||
|---|---|---|---|---|
| CAS Number | 857652-30-3 | Molecular Weight | 360.408 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 513.8±60.0 °C at 760 mmHg | |
| Molecular Formula | C18H24N4O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 264.5±32.9 °C | |
Use of PSN632408PSN632408 is an optimized agonist of GPR119 receptors that shows similar potency to OEA at both recombinant mouse and human GPR119 receptors, exhibiting EC50 values of 5.6 and 7.9 uM, respectively.IC50 value: 5.6/7.9 uM ( recombinant mouse/ human GPR119) [1]Target: GPR119 agonistSystemic administration of PSN632408 (30 mg/kgintraperitoneally) suppresses food intake, reduces weight gain, and white adipose tissue deposition in rats. GPR119 (previously designated SNORF25) is an orphan G protein-coupled receptor expressed predominantly in the pancreas and gastrointestinal tract in humans and in the brain, pancreas, and gastrointestinal tract in rodents. It mediates a reduction in food intake and body weight gain in rats upon treatment with oleoyl ethanolamide (OEA), an endogenous, potent agonist for PPARα. These data suggest that PSN632408 may be useful as a therapeutic agent for the treatment of obesity. |
| Name | tert-butyl 4-[(3-pyridin-4-yl-1,2,4-oxadiazol-5-yl)methoxy]piperidine-1-carboxylate |
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| Synonym | More Synonyms |
| Description | PSN632408 is an optimized agonist of GPR119 receptors that shows similar potency to OEA at both recombinant mouse and human GPR119 receptors, exhibiting EC50 values of 5.6 and 7.9 uM, respectively.IC50 value: 5.6/7.9 uM ( recombinant mouse/ human GPR119) [1]Target: GPR119 agonistSystemic administration of PSN632408 (30 mg/kgintraperitoneally) suppresses food intake, reduces weight gain, and white adipose tissue deposition in rats. GPR119 (previously designated SNORF25) is an orphan G protein-coupled receptor expressed predominantly in the pancreas and gastrointestinal tract in humans and in the brain, pancreas, and gastrointestinal tract in rodents. It mediates a reduction in food intake and body weight gain in rats upon treatment with oleoyl ethanolamide (OEA), an endogenous, potent agonist for PPARα. These data suggest that PSN632408 may be useful as a therapeutic agent for the treatment of obesity. |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 513.8±60.0 °C at 760 mmHg |
| Molecular Formula | C18H24N4O4 |
| Molecular Weight | 360.408 |
| Flash Point | 264.5±32.9 °C |
| Exact Mass | 360.179749 |
| PSA | 90.58000 |
| LogP | 2.19 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.564 |
| Storage condition | 2-8℃ |
| 2-Methyl-2-propanyl 4-{[3-(4-pyridinyl)-1,2,4-oxadiazol-5-yl]methoxy}-1-piperidinecarboxylate |
| PSN-632,408 |
| 1-Piperidinecarboxylic acid, 4-[[3-(4-pyridinyl)-1,2,4-oxadiazol-5-yl]methoxy]-, 1,1-dimethylethyl ester |
| PSN632408 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: PSN632408
- Price: Negotiable
- Purity: 99.0%
- Delivery: 10 Day
- Contact: Tom
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: PSN632408
- Price: $700.0/100mg $1250.0/250mg $2500.0/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: PSN632408
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcbio.cn
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: PSN632408
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
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Price: $113/10mM*1mLinDMSO
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