DRAinh-A250
Modify Date: 2024-01-15 12:04:06
DRAinh-A250 structure
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Common Name | DRAinh-A250 | ||
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| CAS Number | 858747-13-4 | Molecular Weight | 417.250 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 601.7±55.0 °C at 760 mmHg | |
| Molecular Formula | C20H17BrO5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 317.7±31.5 °C | |
Use of DRAinh-A250DRAinh-A250 is a specific inhibitor of Cl-/anion exchanger SLC26A3 (DRA), fully and reversibly inhibits SLC26A3-mediated Cl- exchange with HCO3-, I-, and thiocyanate (SCN-) with IC50 of ~0.2 uM; does not inhibit the homologous anion exchangers SLC26A4 (pendrin) or SLC26A6 (PAT-1), as well as other related proteins or intestinal ion channels; blocked fluid absorption in closed colonic loops but not in jejunal loops in mice, while the NHE3 (SLC9A3) inhibitor tenapanor blocked absorption only in the jejunum; reduces signs of constipation in loperamide-treated mice after oral treatment. |
| Name | {7-[(3-Bromobenzyl)oxy]-4,8-dimethyl-2-oxo-2H-chromen-3-yl}acetic acid |
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| Synonym | More Synonyms |
| Description | DRAinh-A250 is a specific inhibitor of Cl-/anion exchanger SLC26A3 (DRA), fully and reversibly inhibits SLC26A3-mediated Cl- exchange with HCO3-, I-, and thiocyanate (SCN-) with IC50 of ~0.2 uM; does not inhibit the homologous anion exchangers SLC26A4 (pendrin) or SLC26A6 (PAT-1), as well as other related proteins or intestinal ion channels; blocked fluid absorption in closed colonic loops but not in jejunal loops in mice, while the NHE3 (SLC9A3) inhibitor tenapanor blocked absorption only in the jejunum; reduces signs of constipation in loperamide-treated mice after oral treatment. |
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| References | References 1. Haggie PM, et al. JCI Insight. 2018 Jul 26;3(14). pii: 121370. View Related Products by Target Chloride Channel |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 601.7±55.0 °C at 760 mmHg |
| Molecular Formula | C20H17BrO5 |
| Molecular Weight | 417.250 |
| Flash Point | 317.7±31.5 °C |
| Exact Mass | 416.025940 |
| LogP | 5.12 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.619 |
| 2H-1-Benzopyran-3-acetic acid, 7-[(3-bromophenyl)methoxy]-4,8-dimethyl-2-oxo- |
| {7-[(3-Bromobenzyl)oxy]-4,8-dimethyl-2-oxo-2H-chromen-3-yl}acetic acid |