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858747-13-4

858747-13-4 structure
858747-13-4 structure
  • Name: DRAinh-A250
  • Chemical Name: {7-[(3-Bromobenzyl)oxy]-4,8-dimethyl-2-oxo-2H-chromen-3-yl}acetic acid
  • CAS Number: 858747-13-4
  • Molecular Formula: C20H17BrO5
  • Molecular Weight: 417.250
  • Create Date: 2020-01-12 11:25:50
  • Modify Date: 2024-01-15 12:04:06
  • DRAinh-A250 is a specific inhibitor of Cl-/anion exchanger SLC26A3 (DRA), fully and reversibly inhibits SLC26A3-mediated Cl- exchange with HCO3-, I-, and thiocyanate (SCN-) with IC50 of ~0.2 uM; does not inhibit the homologous anion exchangers SLC26A4 (pendrin) or SLC26A6 (PAT-1), as well as other related proteins or intestinal ion channels; blocked fluid absorption in closed colonic loops but not in jejunal loops in mice, while the NHE3 (SLC9A3) inhibitor tenapanor blocked absorption only in the jejunum; reduces signs of constipation in loperamide-treated mice after oral treatment.

Name {7-[(3-Bromobenzyl)oxy]-4,8-dimethyl-2-oxo-2H-chromen-3-yl}acetic acid
Synonyms 2H-1-Benzopyran-3-acetic acid, 7-[(3-bromophenyl)methoxy]-4,8-dimethyl-2-oxo-
{7-[(3-Bromobenzyl)oxy]-4,8-dimethyl-2-oxo-2H-chromen-3-yl}acetic acid
Description DRAinh-A250 is a specific inhibitor of Cl-/anion exchanger SLC26A3 (DRA), fully and reversibly inhibits SLC26A3-mediated Cl- exchange with HCO3-, I-, and thiocyanate (SCN-) with IC50 of ~0.2 uM; does not inhibit the homologous anion exchangers SLC26A4 (pendrin) or SLC26A6 (PAT-1), as well as other related proteins or intestinal ion channels; blocked fluid absorption in closed colonic loops but not in jejunal loops in mice, while the NHE3 (SLC9A3) inhibitor tenapanor blocked absorption only in the jejunum; reduces signs of constipation in loperamide-treated mice after oral treatment.
References References 1. Haggie PM, et al. JCI Insight. 2018 Jul 26;3(14). pii: 121370. View Related Products by Target Chloride Channel
Density 1.5±0.1 g/cm3
Boiling Point 601.7±55.0 °C at 760 mmHg
Molecular Formula C20H17BrO5
Molecular Weight 417.250
Flash Point 317.7±31.5 °C
Exact Mass 416.025940
LogP 5.12
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.619
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