cGAS-IN-1

Modify Date: 2025-08-25 20:09:13

cGAS-IN-1 structure	Common Name	cGAS-IN-1
	CAS Number	858770-07-7	Molecular Weight	377.35
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₉NO₈	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of cGAS-IN-1

cGAS-IN-1 (compound C20) is a flavonoid and Cyclic GMP-AMP Synthase (cGAS) inhibitor with IC50s of 2.28 μM (human cGAS) and 1.44 μM (mouse cGAS). Abnormal activation of cGAS is associated with a variety of immune-mediated inflammatory diseases, and cGAS-IN-1 has potential anti-inflammatory activity[1].

Name	cGAS-IN-1

Description	cGAS-IN-1 (compound C20) is a flavonoid and Cyclic GMP-AMP Synthase (cGAS) inhibitor with IC50s of 2.28 μM (human cGAS) and 1.44 μM (mouse cGAS). Abnormal activation of cGAS is associated with a variety of immune-mediated inflammatory diseases, and cGAS-IN-1 has potential anti-inflammatory activity[1].
Related Catalog	Research Areas >> Inflammation/Immunology
Target	IC50: 2.28 μM (human cGAS); 1.44 μM (mouse cGAS)[1]
References	[1]. Li J, et al. Discovery of novel cGAS inhibitors based on natural flavonoids. Bioorg Chem. 2023 Nov;140:106802.. .

Molecular Formula	C₁₈H₁₉NO₈
Molecular Weight	377.35

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cGAS-IN-1

Use of cGAS-IN-1

Names

cGAS-IN-1 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.