AGN 205728
Modify Date: 2025-08-23 18:33:15
AGN 205728 structure
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Common Name | AGN 205728 | ||
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| CAS Number | 859498-05-8 | Molecular Weight | 437.53000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H27NO3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AGN 205728AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/ 0.6 nM; no inhibiton on RARα and RARβ.IC50 value: 3 nM/ 0.6 nM(Ki/IC95)Target: RARγ antagonistMore information can be found in the following patent, Compound 7a.Preparation of disubstituted chalcone oximes having RARγ retinoid receptor antagonist activityBy Tsang, Kwok Yin; Sinha, Santosh; Liu, Xiaoxia; Bhat, Smita; Chandraratna, Roshantha A.From PCT Int. Appl. (2005), WO 2005066115 A2 20050721. |
| Name | Benzoic acid, 4-[(1E,3E)-3-[7,8-dihydro-8,8-dimethyl-5-(4-methylphenyl)-2-naphthalenyl]-3-(hydroxyimino)-1-propen-1-yl] |
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| Synonym | More Synonyms |
| Description | AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/ 0.6 nM; no inhibiton on RARα and RARβ.IC50 value: 3 nM/ 0.6 nM(Ki/IC95)Target: RARγ antagonistMore information can be found in the following patent, Compound 7a.Preparation of disubstituted chalcone oximes having RARγ retinoid receptor antagonist activityBy Tsang, Kwok Yin; Sinha, Santosh; Liu, Xiaoxia; Bhat, Smita; Chandraratna, Roshantha A.From PCT Int. Appl. (2005), WO 2005066115 A2 20050721. |
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| Related Catalog | |
| References |
| Molecular Formula | C29H27NO3 |
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| Molecular Weight | 437.53000 |
| Exact Mass | 437.19900 |
| PSA | 69.89000 |
| LogP | 6.69790 |
| Storage condition | 2-8℃ |
| Benzoic acid, 4-[(1E,3E)-3-[7,8-dihydro-8,8-dimethyl-5-(4-methylphenyl)-2-naphthalenyl]-3-(hydroxyimino)-1-propenyl]- |
| E-4-[3-(8,8-Dimethyl-5-p-tolyl-7,8-dihydronaphthalen-2-yl)-3-hydroxyiminopropenyl]benzoic acid |
| AGN 205728 |