C-021
Modify Date: 2024-01-21 23:57:41
C-021 structure
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Common Name | C-021 | ||
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| CAS Number | 864289-85-0 | Molecular Weight | 467.65 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H41N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of C-021C-021 is a potent CC chemokine receptor-4 (CCR4) antagonist. C-021 potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM, respectively. C-021 effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor with an IC50 of 18 nM[1]. |
| Name | 2-([1,4'-bipiperidin]-1'-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine |
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| Synonym | More Synonyms |
| Description | C-021 is a potent CC chemokine receptor-4 (CCR4) antagonist. C-021 potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM, respectively. C-021 effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor with an IC50 of 18 nM[1]. |
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| Related Catalog | |
| Target |
CCR4 |
| In Vitro | The in vitro oxidative metabolic stability of C-021 (Compound 1b) is evaluated by measuring the rate of drug consumption in human liver microsomes (HML), thus providing intrinsic clearance values (CLint). C-021 exhibits CLint value of 17,377 mL/h/kg[1]. |
| In Vivo | The potency of C-021 (Compound 1b) is evident after subcutaneous administration in the murine oxazolone-induced contact hypersensitivity test, a known model of acute skin inflammation. When C-021 is administered orally, however, very little inhibition is observed[1]. C-021 (1 mg/kg; i.p.; daily; for 3 days) significantly less microgliosis in acute liver failuremice[2]. Animal Model: Male C57Bl/6 mice (20-25 g) with acute liver failure[2] Dosage: 1 mg/kg Administration: i.p.; daily; for 3 days Result: Significantly less microgliosis, and significantly reduced the pERK1/2 to tERK1/2 ratio. |
| References |
| Molecular Formula | C27H41N5O2 |
|---|---|
| Molecular Weight | 467.65 |
| Exact Mass | 467.32600 |
| PSA | 62.75000 |
| LogP | 5.31230 |
| 2-(1,4'-BIPIPERIDIN)-1'-YL-N-CYCLOHEPTYL-6,7-DIMETHOXY-4-QUINAZOLINAMINE |
| C 021 dihydrochloride |