3,4,5-Tricaffeoylquinic acid

Modify Date: 2024-01-02 21:52:36

3,4,5-Tricaffeoylquinic acid structure	Common Name	3,4,5-Tricaffeoylquinic acid
	CAS Number	86632-03-3	Molecular Weight	678.59
	Density	1.6±0.1 g/cm3	Boiling Point	916.0±65.0 °C at 760 mmHg
	Molecular Formula	C₃₄H₃₀O₁₅	Melting Point	N/A
	MSDS	N/A	Flash Point	290.9±27.8 °C

Use of 3,4,5-Tricaffeoylquinic acid

3,4,5-Tricaffeoylquinic acid is isolated from barks of Ilex rotunda Thunb, used in the research of the pro-inflammatory mediator-induced skin disease[1].

Name	(3R,5R)-3,4,5-tris[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-1-hydroxycyclohexane-1-carboxylic acid
Synonym	More Synonyms

Description	3,4,5-Tricaffeoylquinic acid is isolated from barks of Ilex rotunda Thunb, used in the research of the pro-inflammatory mediator-induced skin disease[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	3,4,5-Tricaffeoylquinic acid (0-50 μM) reduces TNF-α-induced production of cytokines in HEK001 keratinocytes[1]. 3,4,5-Tricaffeoylquinic acid (15 μM, 35 min) inhibits TNF-α-induced IkBα phosphorylation and activation of NF-κB[1]. Cell Viability Assay[1] Cell Line: Keratinocytes Concentration: 15, 25 and 50 μM Incubation Time: 24 hours Result: Cell death was cell ∼4-5% at 15 and 25 μM, ∼9% at 50 μM. Western Blot Analysis[1] Cell Line: Keratinocytes Concentration: 15 μM Incubation Time: 20 min before 10 ng/mL TNF-α addition for 15 min Result: Decreased TNF-α-induced-IkBα phosphorylation of IkBα and levels of cytosolic NF-Κb p65, cytosolic NF-Κb p65.
References	[1]. Lee CS, et al. 3,4,5-Tricaffeoylquinic acid inhibits tumor necrosis factor-α-stimulated production of inflammatory mediators in keratinocytes via suppression of Akt- and NF-κB-pathways. Int Immunopharmacol. 2011 Nov;11(11):1715-23.

Density	1.6±0.1 g/cm3
Boiling Point	916.0±65.0 °C at 760 mmHg
Molecular Formula	C₃₄H₃₀O₁₅
Molecular Weight	678.59
Flash Point	290.9±27.8 °C
Exact Mass	678.158447
PSA	257.81000
LogP	2.68
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.737
Storage condition	2-8°C

Cyclohexanecarboxylic acid, 3,4,5-tris(((2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl)oxy)-1-hydroxy-, (1α,3R,4α,5R)-

(3R,5R)-3,4,5-Tris{[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoyl]oxy}-1-hydroxycyclohexanecarboxylic acid

3,4,5-tricaffeoylquinic acid

3,4,5-tri-CQA

Cyclohexanecarboxylic acid, 3,4,5-tris[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-1-hydroxy-, (3R,5R)-

Caffeoylquinic acid der.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 3,4,5-Tricaffeoylquinic acid
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 3,4,5-Tricaffeoylquinic acid
Price: ￥4868.0/5mg ￥7268.0/20mg
Purity: 98.0%
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DC Chemicals Limited
China
Product Name: 3,4,5-tri-cqa
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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