Fasitibant free base
Modify Date: 2024-04-08 16:56:41
Fasitibant free base structure
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Common Name | Fasitibant free base | ||
|---|---|---|---|---|
| CAS Number | 869939-83-3 | Molecular Weight | 764.78 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C36H49Cl2N6O6S+ | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Fasitibant free baseFasitibant (free base) is a potent, selective, high affinity, and long-lasting nonpeptide bradykinin B2 (BK2) receptor antagonist. Fasitibant (free base) has proinflammatory effects and can be used for the research of osteoarthritis and rheumatoid arthritis[1]. |
| Name | Fasitibant free base |
|---|
| Description | Fasitibant (free base) is a potent, selective, high affinity, and long-lasting nonpeptide bradykinin B2 (BK2) receptor antagonist. Fasitibant (free base) has proinflammatory effects and can be used for the research of osteoarthritis and rheumatoid arthritis[1]. |
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| Related Catalog | |
| Target |
Bradykinin B2 Receptor (B2R) |
| In Vitro | Fasitibant (free base) (1 µM；30 min) 减少了滑膜细胞中 BK 诱导的 PGE2 形成和 COX-2 基因表达[1]。 |
| In Vivo | Fasitibant (free base) (100 µg；膝盖注射；单剂量) 显著降低了大鼠中卡拉胶 (Carrageenan，HY-125474) 诱导的 IL-1b、IL-6、GRO/CINC-1 滑膜细胞因子的释放，PGE 代谢产物的形成，髓过氧化物酶 (MPO) 的活性，当与地塞米松 (Dexamethasone，HY-14648) 联用时效果更显著[2]。 |
| References |
| Molecular Formula | C36H49Cl2N6O6S+ |
|---|---|
| Molecular Weight | 764.78 |