K 114

Modify Date: 2024-01-02 15:58:57

K 114 Structure
K 114 structure
Common Name K 114
CAS Number 872201-12-2 Molecular Weight 393.27
Density N/A Boiling Point N/A
Molecular Formula C22H17BrO2 Melting Point N/A
MSDS USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

 Use of K 114


K114, a fluorescent Congo Red analogue, binds tightly to amyloid fibrils with an EC50 of 20-30 nM[1].

 Names

Name 4-[(E)-2-[3-bromo-4-[(E)-2-(4-hydroxyphenyl)ethenyl]phenyl]ethenyl]phenol
Synonym More Synonyms

 K 114 Biological Activity

Description K114, a fluorescent Congo Red analogue, binds tightly to amyloid fibrils with an EC50 of 20-30 nM[1].
Related Catalog
References

[1]. LeVine H 3rd, et al. Mechanism of A beta(1-40) fibril-induced fluorescence of (trans,trans)-1-bromo-2,5-bis(4-hydroxystyryl)benzene (K114). Biochemistry. 2005 Dec 6;44(48):15937-43.

 Chemical & Physical Properties

Molecular Formula C22H17BrO2
Molecular Weight 393.27
Exact Mass 392.04100
PSA 40.46000
LogP 6.20110

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H319-H413
Precautionary Statements P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
RIDADR NONH for all modes of transport

 Articles1

More Articles
Coaggregation of RNA-binding proteins in a model of TDP-43 proteinopathy with selective RGG motif methylation and a role for RRM1 ubiquitination.

PLoS ONE 7 , e38658, (2012)

TAR DNA-binding protein 43 (TDP-43) is a major component within ubiquitin-positive inclusions of a number of neurodegenerative diseases that increasingly are considered as TDP-43 proteinopathies. Iden...

 Synonyms

k114
hms3263m09
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