Filibuvir
Modify Date: 2024-01-04 18:21:42
Filibuvir structure
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Common Name | Filibuvir | ||
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| CAS Number | 877130-28-4 | Molecular Weight | 503.63600 | |
| Density | 1.29g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C29H37N5O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of FilibuvirFilibuvir is a potent, selective non-nucleoside inhibitor (NNI) of the HCV nonstructural 5B protein (NS5B) RNA-dependent RNA polymerase, and it binds noncovalently in the “Thumb 2” pocket of NS5B. In vitro, filibuvir is equipotent against genotype 1a and 1b replicons, with an EC50 of 59 nM[1]. |
| Name | (2R)-2-cyclopentyl-2-[2-(2,6-diethylpyridin-4-yl)ethyl]-5-[(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl]-4-hydroxy-3H-pyran-6-one |
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| Synonym | More Synonyms |
| Description | Filibuvir is a potent, selective non-nucleoside inhibitor (NNI) of the HCV nonstructural 5B protein (NS5B) RNA-dependent RNA polymerase, and it binds noncovalently in the “Thumb 2” pocket of NS5B. In vitro, filibuvir is equipotent against genotype 1a and 1b replicons, with an EC50 of 59 nM[1]. |
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| Related Catalog | |
| References |
| Density | 1.29g/cm3 |
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| Molecular Formula | C29H37N5O3 |
| Molecular Weight | 503.63600 |
| Exact Mass | 503.29000 |
| PSA | 102.50000 |
| LogP | 5.12420 |
| Appearance of Characters | white to beige |
| Storage condition | room temp |
| Water Solubility | DMSO: soluble10mg/mL, clear |
| RIDADR | NONH for all modes of transport |
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| Filibuvir |
| 3frz |
| UNII-198J479Y2L |