Fostriecin
Fostriecin structure
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Common Name | Fostriecin | ||
|---|---|---|---|---|
| CAS Number | 87860-39-7 | Molecular Weight | 452.36800 | |
| Density | N/A | Boiling Point | 737.9ºC at 760 mmHg | |
| Molecular Formula | C19H26NaO9P | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 400.1ºC | |
Use of FostriecinFostriecin is an inhibitor of the serine/threonine protein phosphatases 2A (PP2A) and 4 (PP4) |
| Name | Fostriecin sodium salt,(6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-onesodiumsalt |
|---|---|
| Synonym | More Synonyms |
| Boiling Point | 737.9ºC at 760 mmHg |
|---|---|
| Molecular Formula | C19H26NaO9P |
| Molecular Weight | 452.36800 |
| Flash Point | 400.1ºC |
| Exact Mass | 452.12100 |
| PSA | 166.39000 |
| LogP | 1.49330 |
| Storage condition | −20°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | UQ0600000 |
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Dopamine D2 receptor activity modulates Akt signaling and alters GABAergic neuron development and motor behavior in zebrafish larvae.
J. Neurosci. 31 , 5512-25, (2011) An imbalance in dopamine-mediated neurotransmission is a hallmark physiological feature of neuropsychiatric disorders, such as schizophrenia. Recent evidence demonstrates that dopamine D(2) receptors,... |
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Fostriecin-mediated G2-M-phase growth arrest correlates with abnormal centrosome replication, the formation of aberrant mitotic spindles, and the inhibition of serine/threonine protein phosphatase activity.
Cancer Res. 58 , 3611-3619, (1998) Fostriecin, a structurally unique phosphate ester, is presently under evaluation in clinical trials to determine its potential use as an antitumor drug in humans. Fostriecin has been reported as havin... |
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Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A.
FEBS Lett. 416 , 230, (1997) Fostriecin, an antitumor antibiotic produced by Streptomyces pulveraceus, is a strong inhibitor of type 2A (PP2A; IC50 3.2 nM) and a weak inhibitor of type 1 (PP1; IC50 131 microM) serine/threonine pr... |
| PHOSPHOTRIENIN |
| FOSTRIECIN SODIUM SALT |
| cl1565asodiumsalt |
| FOSTRIECIN |
| FST |
| antibioticcl1565asodiumsalt |
| MFCD01939908 |
| FOSTRIECIN SODIUM |
| CL-920 |
| ci920sodiumsalt |
| antibioticci920sodiumsalt |