ECKOL
Modify Date: 2025-08-26 00:03:18
ECKOL structure
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Common Name | ECKOL | ||
|---|---|---|---|---|
| CAS Number | 88798-74-7 | Molecular Weight | 372.28200 | |
| Density | 1.778g/cm3 | Boiling Point | 685.5ºC at 760 mmHg | |
| Molecular Formula | C18H12O9 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 368.4ºC | |
Use of ECKOLEckol is a potent hMAO-A (Mixed) and hMAO-B (non-competitive) inhibitor with IC50s of 7.20 and 83.44 μM, respectively. Eckol shows stimulatory effects in maize and can be used as a plant biostimulant. Eckol also shows antiallergic and antiviral effects[1][2][3][4]. |
| Name | eckol |
|---|---|
| Synonym | More Synonyms |
| Description | Eckol is a potent hMAO-A (Mixed) and hMAO-B (non-competitive) inhibitor with IC50s of 7.20 and 83.44 μM, respectively. Eckol shows stimulatory effects in maize and can be used as a plant biostimulant. Eckol also shows antiallergic and antiviral effects[1][2][3][4]. |
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| Related Catalog | |
| Target |
hMAO-A:7.20 μM (IC50) hMAO-B:83.44 μM (IC50) H1N1:89.5 μM (IC50) |
| In Vitro | Eckol (25-100 μg/mL; 2 h) 预处理以剂量依赖的方式显著降低 IgE/BSA 刺激的 BMCMC 中 β-hexosaminidase 的释放[3]。 Eckol (25-100 μg/mL; 1 h) 抑制 Th2 型细胞因子的产生，如 IL-4、IL-5、 IL-13 以及促炎细胞因子，如 IL-6[3]。 Eckol (25-100 μg/mL) 减弱 IgE/BSA 刺激的 BMCMC 细胞中细胞因子 mRNA 水平，如IL-1β、IL-4、IL-5、IL-6、IL-13、IFN-γ 和 TNF-α[3]。 Eckol (25-100 μg/mL; 1 h) 在 IgE/BSA 刺激的 BMCMC 中抑制 NF-κB 的激活[3]。 Eckol 抑制 influenza A/Bervig-Mission/1/18 (H1N1) 病毒，IC50 为 89.5 µM[4]。 Western Blot Analysis[3] Cell Line: Bone marrow-derived cultured mast cells (BMCMC) Concentration: 25, 50 and 100 μg/mL Incubation Time: 1 h Result: Inhibited the degradation of IκB-α within the cytosol and the translocation of the NF-κB/p65 subunit into the nucleus that were induced by IgE/BSA. |
| In Vivo | 叶面喷施 Eckol (1 μM) 显著提高了茎长和根长、茎干鲜重、叶面积和叶数[2]。 Eckol (50 or 100 μg/mouse; intradermal; once) 降低被动皮肤过敏反应 (PCA) 诱导小鼠的过敏性炎症反应[3]。 Animal Model: BALB/c mice (8 weeks old), IgE/BSA-induced passive cutaneous anaphylaxis (PCA) model[3] Dosage: 50 or 100 μg/mouse Administration: Intradermal injection, applied on mice ear 2 h prior to anaphylaxis induction Result: Reduced allergic inflammatory responses. |
| References |
| Density | 1.778g/cm3 |
|---|---|
| Boiling Point | 685.5ºC at 760 mmHg |
| Molecular Formula | C18H12O9 |
| Molecular Weight | 372.28200 |
| Flash Point | 368.4ºC |
| Exact Mass | 372.04800 |
| PSA | 149.07000 |
| LogP | 3.61050 |
| Index of Refraction | 1.807 |
| InChIKey | PCZZRBGISTUIOA-UHFFFAOYSA-N |
| SMILES | Oc1cc(O)cc(Oc2c(O)cc(O)c3c2Oc2c(O)cc(O)cc2O3)c1 |
| HS Code | 2932999099 |
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| HS Code | 2932999099 |
|---|---|
| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Eckol |
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