Pulegone

Modify Date: 2026-07-03 13:28:40

Pulegone structure	Common Name	Pulegone
	CAS Number	89-82-7	Molecular Weight	152.233
	Density	0.9±0.1 g/cm3	Boiling Point	224.0±0.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₆O	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	82.2±0.0 °C
	Symbol	GHS07, GHS08	Signal Word	Warning

Use of Pulegone

Pulegone, the major chemical constituent of Calamintha nepeta (L.) Savi essential oil which is an aromatic herb with a mint-oregano flavor, is one of avian repellents[1]. The molecular target for the repellent action of Pulegone in avian species is nociceptive TRP ankyrin 1 (TRPA1). Pulegone stimulates both TRPM8 and TRPA1 channel in chicken sensory neurons and suppresses the former but not the latter at high concentrations[2].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	(+)-pulegone
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Pulegone, the major chemical constituent of Calamintha nepeta (L.) Savi essential oil which is an aromatic herb with a mint-oregano flavor, is one of avian repellents[1]. The molecular target for the repellent action of Pulegone in avian species is nociceptive TRP ankyrin 1 (TRPA1). Pulegone stimulates both TRPM8 and TRPA1 channel in chicken sensory neurons and suppresses the former but not the latter at high concentrations[2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Others
References	[1]. Božović M, et al. Calamintha nepeta (L.) Savi and its Main Essential Oil Constituent Pulegone: Biological Activities and Chemistry. Molecules. 2017 Feb 14;22(2). [2]. Majikina A, et al. Involvement of nociceptive transient receptor potential channels in repellent action of pulegone. Biochem Pharmacol. 2018 May;151:89-95.

Description

Related Catalog

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Others

References

[1]. Božović M, et al. Calamintha nepeta (L.) Savi and its Main Essential Oil Constituent Pulegone: Biological Activities and Chemistry. Molecules. 2017 Feb 14;22(2).

[2]. Majikina A, et al. Involvement of nociceptive transient receptor potential channels in repellent action of pulegone. Biochem Pharmacol. 2018 May;151:89-95.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	0.9±0.1 g/cm3
Boiling Point	224.0±0.0 °C at 760 mmHg
Molecular Formula	C₁₀H₁₆O
Molecular Weight	152.233
Flash Point	82.2±0.0 °C
Exact Mass	152.120117
PSA	17.07000
LogP	2.56
Vapour Pressure	0.1±0.4 mmHg at 25°C
Index of Refraction	1.470
InChIKey	NZGWDASTMWDZIW-MRVPVSSYSA-N
SMILES	CC(C)=C1CCC(C)CC1=O
Storage condition	2-8°C

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

Pulegone MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OT0261000

CHEMICAL NAME :: p-Menth-4(8)-en-3-one, (R)-(+)-

CAS REGISTRY NUMBER :: 89-82-7

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H16-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 330 mg/kg

TOXIC EFFECTS :: Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section

REFERENCE :: COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV. Volume(issue)/page/year: 236,633,1953

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS07, GHS08
Signal Word	Warning
Hazard Statements	H302-H351-H412
Precautionary Statements	P273-P301 + P312 + P330
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	S23-S24/25
RIDADR	2810
WGK Germany	3
RTECS	OT0261000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2914299000

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 9
CAS#:7786-67-6 Isopulegol CAS#:491-09-8 Piperitenone CAS#:308358-04-5 (R)-Pulegone Oxide CAS#:594-19-4 Tert-Butyllithium
CAS#:66448-75-7 2-(2-chloroprop... CAS#:37586-57-5 magnesium,2-met... CAS#:86613-13-0 2-(2-bromopropa... CAS#:235093-69-3 N-(phenylseleno...
CAS#:323999-92-4 8-amino-N-pheny...
DownStream 9
CAS#:106550-07-6 2-methyl-6-phen... CAS#:491-09-8 Piperitenone CAS#:35736-66-4 (5R)-5-methyl-2... CAS#:3304-24-3 Cyclohexanone,2...
CAS#:87791-00-2 2-Cyclohexen-1-... CAS#:494-90-6 UNII:LK024V9U3C CAS#:65253-04-5 (-)-8-Phenylmenthol CAS#:591-24-2 UNII:255L4HTY2B
CAS#:89-83-8 Thymol

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2914299000
Summary	2914299000. other cyclanic, cyclenic or cyclotherpenic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

R(+)-pulegone impairs Ca²+ homeostasis and causes negative inotropism in mammalian myocardium.

Eur. J. Pharmacol. 672(1-3) , 135-42, (2011)

The present study aimed to investigate the inotropic effects of R(+)-pulegone, a monoterpene found in plant species belonging to the genus Mentha, on the mammalian heart. In electrically stimulated gu...

Synthesis of (R)-(+)-4-methylcyclohex-2-ene-1-one.

J. Org. Chem. 77(20) , 9422-5, (2012)

A three-step synthesis of (R)-(+)-4-methylcyclohex-2-ene-1-one (1) from (R)-(+)-pulegone (3), proceeding in 44% overall yield, is described. The sequence comprises vinyl triflate formation, site-selec...

Intraspecific variability of the essential oil of Calamintha nepeta subsp. nepeta from Southern Italy (Apulia).

Nat. Prod. Res. 27(4-5) , 331-9, (2013)

The essential oil of 46 spontaneous plants of Calamintha nepeta (L.) Savi subsp. nepeta growing wild in Sud, Italy (Salento, Apulia), were investigated by GC/MS. Fifty-seven components were identified...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482

Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS ...
Source: 824
Target: N/A
External Id: P53MS837

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS898

Name: Adrenergic beta2 receptor (ADRB2) small molecule agonists, cell-based qHTS assay
Source: 824
External Id: ADRB2293

Name: Adrenergic beta2 receptor (ADRB2) small molecule antagonists, cell-based qHTS assay
Source: 824
External Id: ADRB2713

Total 202, Current Page 1 of 21

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

(5R)-5-methyl-2-(methylethylidene)cyclohexan-1-one

(5R)-2-Isopropylidéne-5-méthylcyclohexanone

(R)-Pulegone

PULEGON

MFCD00063000

PULEGONE,TECH

2-isopropylidene-5-methylcyclohexan-1-one

EINECS 201-943-2

(5R)-5-Methyl-2-(2-propanyliden)cyclohexanon

(+)-(R)-Pulegone

D-PULEGONE

R-(+)-Pulegone

Pulegone,(d)

(1R)-(+)-pulegone

(5R)-2-Isopropylidene-5-methylcyclohexanone

(+)-Pulegone

R-(+)-p-Menth-4(8)-en-3-one

FEMA 2963

Pulegone

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the SMILES notation of (+)-pulegone?

A: SMILES notation of (+)-pulegone is CC(C)=C1CCC(C)CC1=O.

Q: What is the InChIKey of (+)-pulegone?

A: InChIKey of (+)-pulegone is NZGWDASTMWDZIW-MRVPVSSYSA-N.

Q: What are the uses of (+)-pulegone?

A: Main uses of (+)-pulegone: Pulegone, the major chemical constituent of Calamintha nepeta (L.) Savi essential oil which is an aromatic herb with a mint-oregano flavor, is one of avian repellents[1]. The molecular target for the repellent action of Pulegone in avian species is nociceptive TRP ankyrin 1 (TRPA1). Pulegone stimulates both TRPM8 and TRPA1 channel in chicken sensory neurons and suppresses the former but not the latter at high concentrations[2].

Q: What is the LogP of (+)-pulegone?

A: LogP of (+)-pulegone is 2.56.

Q: What is the polar surface area (PSA) of (+)-pulegone?

A: Polar surface area (PSA) of (+)-pulegone is 17.07000.

Q: What is the English name of (+)-pulegone?

A: The English name of (+)-pulegone is (+)-pulegone.

Q: What is the boiling point of (+)-pulegone?

A: Boiling point of (+)-pulegone is 224.0±0.0 °C at 760 mmHg.

Q: What English synonyms does (+)-pulegone have?

A: English synonyms of (+)-pulegone: (5R)-5-methyl-2-(methylethylidene)cyclohexan-1-one, (5R)-2-Isopropylidéne-5-méthylcyclohexanone, (R)-Pulegone, PULEGON, MFCD00063000, PULEGONE,TECH, 2-isopropylidene-5-methylcyclohexan-1-one, EINECS 201-943-2, (5R)-5-Methyl-2-(2-propanyliden)cyclohexanon, (+)-(R)-Pulegone, D-PULEGONE, R-(+)-Pulegone, Pulegone,(d), (1R)-(+)-pulegone, (5R)-2-Isopropylidene-5-methylcyclohexanone, (+)-Pulegone, R-(+)-p-Menth-4(8)-en-3-one, FEMA 2963, Pulegone.

Q: What are the downstream products of (+)-pulegone?

A: Related downstream products(CAS) of (+)-pulegone: 106550-07-6;491-09-8;35736-66-4;3304-24-3;87791-00-2;494-90-6;65253-04-5;591-24-2;89-83-8.

Q: What is the safety information for (+)-pulegone?

A: Safety information for (+)-pulegone: S23-S24/25.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

naturewill

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Pulegone
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

naturewill
China
Product Name: Pulegone
Price: ￥Inquiry/5mg ￥Inquiry/20mg ￥Inquiry/100mg ￥Inquiry/1g
Purity: 98.0%
Delivery: Inquiry
Contact: Bella
Email: 3157321941@qq.com

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