2-BFI hydrochloride

Modify Date: 2025-09-14 11:03:44

2-BFI hydrochloride structure	Common Name	2-BFI hydrochloride
	CAS Number	89196-95-2	Molecular Weight	222.67
	Density	N/A	Boiling Point	348.1ºC at 760 mmHg
	Molecular Formula	C₁₁H₁₁ClN₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	164.4ºC

Use of 2-BFI hydrochloride

RX 801077 hydrochloride (2 BFI) is a selective imidazoline I2 receptor (I2R) agonist with a Ki value of 70.1 nM. RX 801077 hydrochlorideshows anti-inflammation and neuroprotection. RX 801077 hydrochloride has the potential for the research of traumatic brain injury (TBI)[1][2].

Name	2-(1-benzofuran-2-yl)-4,5-dihydro-1H-imidazole,hydrochloride
Synonym	More Synonyms

Description	RX 801077 hydrochloride (2 BFI) is a selective imidazoline I2 receptor (I2R) agonist with a Ki value of 70.1 nM. RX 801077 hydrochlorideshows anti-inflammation and neuroprotection. RX 801077 hydrochloride has the potential for the research of traumatic brain injury (TBI)[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Imidazoline Receptor Signaling Pathways >> GPCR/G Protein >> Imidazoline Receptor Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	Ki: 70.1 nM (imidazoline I2 receptor)[1]
In Vivo	RX 801077 hydrochloride (5、10、20 mg/kg；腹腔注射；每天两次，持续 3 天) 在创伤性脑损伤大鼠模型中抑制 NLRP3 炎性体诱导的炎症和坏死性凋亡[2]。 Animal Model: 280-300 g, Male adult Sprague-Dawley rats (TBI model)[2] Dosage: 5, 10, 20 mg/kg Administration: I.p.; twice daily for 3 days Result: Attenuated neurological deficits, brain edema, BBB permeability and cortical tissue loss in a rat model of TBI, reduced microglial activation, neutrophil infiltration, and proinflammatory cytokine IL-1β secretion, reduced the expression of RIP1 and RIP3 in neurons in the pericontusional cortex.
References	[1]. Carpéné C, et al. Inhibition of amine oxidase activity by derivatives that recognize imidazoline I2 sites. J Pharmacol Exp Ther. 1995 Feb;272(2):681-8. [2]. Ni H, et al. 2-BFI Provides Neuroprotection Against Inflammation and Necroptosis in a Rat Model of Traumatic Brain Injury. Front Neurosci. 2019 Jun 26;13:674.

Boiling Point	348.1ºC at 760 mmHg
Molecular Formula	C₁₁H₁₁ClN₂O
Molecular Weight	222.67
Flash Point	164.4ºC
Exact Mass	222.05600
PSA	37.53000
LogP	2.34900
InChIKey	RFNFFVDVGWOSNZ-UHFFFAOYSA-N
SMILES	Cl.c1ccc2oc(C3=NCCN3)cc2c1

HS Code	2934999090

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Name: Presynaptic alpha-2 adrenergic receptor agonistic activity in mouse vas deferens rela...
Source: ChEMBL
Target: Alpha-2B adrenergic receptor
External Id: CHEMBL646768

Name: Ability to antagonize the inhibitory effect of clonidine on the mouse vas deferens is...
Source: ChEMBL
Target: Alpha-2B adrenergic receptor
External Id: CHEMBL646770

Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4513082

Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4303805

Name: Cell-based high throughput primary assay to identify activators of GPR151
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL
External Id: GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

Name: SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f...
Source: ChEMBL
Target: Replicase polyprotein 1ab
External Id: CHEMBL4495582

Name: Tocris HTS for Inhibitors of Aerobactin Synthetase lucA
Source: 23265
External Id: IucA Pilot Assay Tocris Library

Name: Agonism in vitro at Alpha-1 adrenoceptor determined in rat anococcygeus preparation.
Source: ChEMBL
Target: Alpha-1A adrenergic receptor
External Id: CHEMBL647164

Name: Enzymatic assay of human HDAC6 with commercial peptide substrate
Source: ChEMBL
Target: Histone deacetylase 6
External Id: CHEMBL4808149

Name: Enzymatic assay of human HDAC6 with custom peptide substrate
Source: ChEMBL
Target: Histone deacetylase 6
External Id: CHEMBL4808150

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2-BFI hydrochloride

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2-BFI hydrochloride

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.