XR-5000

Modify Date: 2024-01-14 11:41:29

XR-5000 Structure
XR-5000 structure
 Common Name XR-5000
CAS Number 89459-25-6 Molecular Weight 293.36300
Density 1.182g/cm3 Boiling Point 544.1ºC at 760 mmHg
Molecular Formula C18H19N3O Melting Point N/A
MSDS N/A Flash Point 282.9ºC

 Use of XR-5000


DACA inhibits two essential nuclear enzymes in vitro, DNA topoisomerase I and DNA topoisomerase (topo) II. DACA stabilises topo I, topo II alpha, and topo II beta cleavable complexes in human leukaemia CCRF-CEM cells[1].

 Names

Name N-[2-(dimethylamino)ethyl]acridine-4-carboxamide
Synonym More Synonyms

 XR-5000 Biological Activity

Description DACA inhibits two essential nuclear enzymes in vitro, DNA topoisomerase I and DNA topoisomerase (topo) II. DACA stabilises topo I, topo II alpha, and topo II beta cleavable complexes in human leukaemia CCRF-CEM cells[1].
Related Catalog
References

[1]. Padget K, et al. An investigation into the formation of N- [2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) and 6-[2-(dimethylamino)ethylamino]- 3-hydroxy-7H-indeno[2, 1-C]quinolin-7-one dihydrochloride (TAS-103) stabilised DNA topoisomerase I and II cleavable complexes in human leukaemia cells. Biochem Pharmacol. 2000;60(6):817-821.  

 Chemical & Physical Properties

Density 1.182g/cm3
Boiling Point 544.1ºC at 760 mmHg
Molecular Formula C18H19N3O
Molecular Weight 293.36300
Flash Point 282.9ºC
Exact Mass 293.15300
PSA 48.72000
LogP 3.25420
Index of Refraction 1.657
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AR7622610
CHEMICAL NAME :
4-Acridinecarboxamide, N-(2-(dimethylamino)ethyl)-
CAS REGISTRY NUMBER :
89459-25-6
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C18-H19-N3-O
MOLECULAR WEIGHT :
293.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
44597 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
150 nmol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 268,35,1992

 Synthetic Route

N-(2-Formylphenyl)anthranilsaeuremethylester structure

N-(2-Formylphen...

CAS#:188054-38-8

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XR-5000 Structure

XR-5000

CAS#:89459-25-6

Literature: Spicer, Julie A.; Gamage, Swarna A.; Atwell, Graham J.; Finlay, Graeme J.; Baguley, Bruce C.; Denny, William A. Journal of Medicinal Chemistry, 1997 , vol. 40, # 12 p. 1919 - 1929
1,1-Dimethylethylenediamine structure

1,1-Dimethyleth...

CAS#:108-00-9

methyl acridine-4-carboxylate structure

methyl acridine...

CAS#:188054-45-7

~62%

XR-5000 Structure

XR-5000

CAS#:89459-25-6

Literature: Gamage, Swarna A.; Spicer, Julie A.; Rewcastle, Gordon W.; Denny, William A. Tetrahedron Letters, 1997 , vol. 38, # 4 p. 699 - 702 Title/Abstract Full Text View citing articles Show Details Spicer, Julie A.; Gamage, Swarna A.; Atwell, Graham J.; Finlay, Graeme J.; Baguley, Bruce C.; Denny, William A. Journal of Medicinal Chemistry, 1997 , vol. 40, # 12 p. 1919 - 1929
methyl 2-[N-(2-carboxyphenyl)amino]benzoate structure

methyl 2-[N-(2-...

CAS#:100038-81-1

~%

XR-5000 Structure

XR-5000

CAS#:89459-25-6

Literature: Gamage, Swarna A.; Spicer, Julie A.; Rewcastle, Gordon W.; Denny, William A. Tetrahedron Letters, 1997 , vol. 38, # 4 p. 699 - 702
4-CARBOXY-9-ACRIDANONE structure

4-CARBOXY-9-ACR...

CAS#:24782-64-7

~%

XR-5000 Structure

XR-5000

CAS#:89459-25-6

Literature: Atwell, Graham J.; Rewcastle, Gordon W.; Baguley, Bruce C.; Denny, William A. Journal of Medicinal Chemistry, 1987 , vol. 30, # 4 p. 664 - 669

 Synonyms

Acridine carboxamide
N-(2-(Dimethylamino)ethyl)-4-acridinecarboxamide
N-(2-(Dimehtylamino)ehtyl)acridine-4-carboxamide
Daca
4-Acridinecarboxamide,N-(2-(dimethylamino)ethyl)
N-[2-(Dimethyl-amino)ethyl]acridine-4-carboxamide
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