AZ876

Modify Date: 2024-01-02 17:45:44

AZ876 structure	Common Name	AZ876
	CAS Number	898800-26-5	Molecular Weight	439.570
	Density	1.3±0.1 g/cm3	Boiling Point	605.3±65.0 °C at 760 mmHg
	Molecular Formula	C₂₄H₂₉N₃O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	319.9±34.3 °C

Use of AZ876

AZ876 is a novel high-affinity LXR agonist. AZ876 was 25-fold and 2.5-fold more potent than GW3965 (HY-10627) on human (h)LXRα and hLXRβ respectively.(1) AZ876 suppressed up-regulation of hypertrophy- and fibrosis-related genes, and further inhibited prohypertrophic and profibrotic transforming growth factor β (TGFβ)-Smad2/3 signalling.(2) AZ876 prevented TGFβ- and angiotensin II-induced fibroblast collagen synthesis, and inhibited up-regulation of the myofibroblastic marker, α-smooth muscle actin.(3) The reference for administration is 20 umol/kg/day in vivo.

Name	AZ876
Synonym	More Synonyms

Description	AZ876 is a novel high-affinity LXR agonist. AZ876 was 25-fold and 2.5-fold more potent than GW3965 (HY-10627) on human (h)LXRα and hLXRβ respectively.(1) AZ876 suppressed up-regulation of hypertrophy- and fibrosis-related genes, and further inhibited prohypertrophic and profibrotic transforming growth factor β (TGFβ)-Smad2/3 signalling.(2) AZ876 prevented TGFβ- and angiotensin II-induced fibroblast collagen synthesis, and inhibited up-regulation of the myofibroblastic marker, α-smooth muscle actin.(3) The reference for administration is 20 umol/kg/day in vivo.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> LXR Research Areas >> Cancer
References	[1]. Cannon MV et al. The liver X receptor agonist AZ876 protects against pathological cardiac hypertrophy and fibrosis without lipogenic side effects. Eur J Heart Fail. 2015 Mar;17(3):273-82. [2]. van der Hoorn J et al. Low dose of the liver X receptor agonist, AZ876, reduces atherosclerosis in APOE*3Leiden mice without affecting liver or plasma triglyceride levels. Br J Pharmacol. 2011 Apr;162(7):1553-63.

Description

Related Catalog

Signaling Pathways >> Metabolic Enzyme/Protease >> LXR

Research Areas >> Cancer

References

[1]. Cannon MV et al. The liver X receptor agonist AZ876 protects against pathological cardiac hypertrophy and fibrosis without lipogenic side effects. Eur J Heart Fail. 2015 Mar;17(3):273-82.

[2]. van der Hoorn J et al. Low dose of the liver X receptor agonist, AZ876, reduces atherosclerosis in APOE*3Leiden mice without affecting liver or plasma triglyceride levels. Br J Pharmacol. 2011 Apr;162(7):1553-63.

Density	1.3±0.1 g/cm3
Boiling Point	605.3±65.0 °C at 760 mmHg
Molecular Formula	C₂₄H₂₉N₃O₃S
Molecular Weight	439.570
Flash Point	319.9±34.3 °C
Exact Mass	439.192963
LogP	3.27
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.642
Storage condition	2-8℃

MFCD30377191

AZ12260493

2-(2-Methyl-2-propanyl)-5-phenyl-4-{[4-(1-piperidinyl)phenyl]amino}-1,2-thiazol-3(2H)-one 1,1-dioxide

3(2H)-Isothiazolone, 2-(1,1-dimethylethyl)-5-phenyl-4-[[4-(1-piperidinyl)phenyl]amino]-, 1,1-dioxide

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: AZ-876
Price: Click To Check
Purity: 99.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: AZ876
Price: $600.0/100mg $1100.0/250mg $2200.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: AZ876
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

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Price: $406/10mM*1mLinDMSO

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