Phosphoglycerate kinase

Modify Date: 2024-01-08 14:54:46

Phosphoglycerate kinase Structure
Phosphoglycerate kinase structure
Common Name Phosphoglycerate kinase
CAS Number 9001-83-6 Molecular Weight 226.232
Density 1.4±0.1 g/cm3 Boiling Point 656.2±55.0 °C at 760 mmHg
Molecular Formula C9H14N4O3 Melting Point N/A
MSDS Chinese USA Flash Point 350.7±31.5 °C

 Use of Phosphoglycerate kinase


Phosphoglycerate kinase (PGK), namely phosphoglycerate kinase, is a glycolytic enzyme commonly used in biochemical research. Phosphoglycerate kinase can catalyze the reversible transfer of phosphate groups from 1,3-bisphosphoglycerate (1,3-BPG) to ADP to generate 3-phosphoglycerate (3-PG) and ATP. At the same time, it can also participate in gluconeogenesis, catalyzing the opposite reaction to produce 1,3BPGA and ADP. Phosphoglycerate kinase is involved in energy metabolism, interaction with nucleic acid, tumor progression, cell death and virus replication and other related processes[1].

 Names

Name Kinase(Phosphorylating), Phosphoglycerate
Synonym More Synonyms

 Phosphoglycerate kinase Biological Activity

Description Phosphoglycerate kinase (PGK), namely phosphoglycerate kinase, is a glycolytic enzyme commonly used in biochemical research. Phosphoglycerate kinase can catalyze the reversible transfer of phosphate groups from 1,3-bisphosphoglycerate (1,3-BPG) to ADP to generate 3-phosphoglycerate (3-PG) and ATP. At the same time, it can also participate in gluconeogenesis, catalyzing the opposite reaction to produce 1,3BPGA and ADP. Phosphoglycerate kinase is involved in energy metabolism, interaction with nucleic acid, tumor progression, cell death and virus replication and other related processes[1].
Related Catalog
References

[1]. Maura Rojas-Pirela, et al. Phosphoglycerate kinase: structural aspects and functions, with special emphasis on the enzyme from Kinetoplastea. Open Biol. 2020 Nov;10(11):200302.   

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 656.2±55.0 °C at 760 mmHg
Molecular Formula C9H14N4O3
Molecular Weight 226.232
Flash Point 350.7±31.5 °C
Exact Mass 226.106583
LogP -2.17
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.591
Storage condition 2-8°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
RIDADR NONH for all modes of transport

 Articles80

More Articles
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

Sci. Signal. 2 , ra46, (2009)

Protein phosphorylation events during T cell receptor (TCR) signaling control the formation of complexes among proteins proximal to the TCR, the activation of kinase cascades, and the activation of tr...

Initial characterization of the human central proteome.

BMC Syst. Biol. 5 , 17, (2011)

On the basis of large proteomics datasets measured from seven human cell lines we consider their intersection as an approximation of the human central proteome, which is the set of proteins ubiquitous...

The first identification of lysine malonylation substrates and its regulatory enzyme.

Mol. Cell. Proteomics 10(12) , M111.012658, (2011)

Protein post-translational modifications (PTMs) at the lysine residue, such as lysine methylation, acetylation, and ubiquitination, are diverse, abundant, and dynamic. They play a key role in the regu...

 Synonyms

2-[(3-Aminopropanoyl)amino]-3-(1H-imidazol-4-yl)propanoic acid
Histidine, β-alanyl-
MFCD00130301
3-PHOSPHOGLYCERIC PHOSPHOKINASE
N-(3-Aminopropanoyl)histidine
ATP: 3-PHOSPHO-D-GLYCERATE 1-PHOSPHOTRANSFERASE
3-PHOSPHOGLYCERIC PHOSPHOKINASE*FROM RAB BIT MUSCLE
EINECS 232-636-1
EC 2.7.2.3
b-Alanylhistidine
β-Alanylhistidine
carnosine
3-PHOSPHOGLYCERIC PHOSPHOKINASE FROM*BAK ERS YEAST C
3-PHOSPHOGLYCERATE KINASE
3-phosphoglyceric phosphokinase from*bakers yeast
Kinase (phosphorylating), phosphoglycerate