Streptokinase

Modify Date: 2025-08-20 19:47:48

Streptokinase structure	Common Name	Streptokinase
	CAS Number	9002-01-1	Molecular Weight	197.274
	Density	1.1±0.1 g/cm3	Boiling Point	343.9±35.0 °C at 760 mmHg
	Molecular Formula	C₁₁H₁₉NO₂	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	161.8±25.9 °C

Use of Streptokinase

Streptokinase is a bacteria-derived protein and a plasminogen activator. Streptokinase is widely used for the research of the blood-clotting disorders. Streptokinase improves reperfusion blood flow after coronary artery occlusion[1][2].

Name	4-cyclohexylpyrrolidine-2-carboxylic acid
Synonym	More Synonyms

Description	Streptokinase is a bacteria-derived protein and a plasminogen activator. Streptokinase is widely used for the research of the blood-clotting disorders. Streptokinase improves reperfusion blood flow after coronary artery occlusion[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
In Vivo	Sreptokinase (6000 IU/kg in 3 ml of saline; intracoronary; infused at 0.05 ml/min for 60 minutes beginning 30 minutes before reperfusion) maintains reperfusion coronary blood flow through a critical stenosis at a rate similar to baseline levels[2].
References	[1]. Vaughan DE, et al. Streptokinase-induced platelet aggregation. Prevalence and mechanism. Circulation. 1991;84(1):84-91. [2]. Mickelson JK, et al. Streptokinase improves reperfusion blood flow after coronary artery occlusion. Int J Cardiol. 1989;23(3):373-384.

Density	1.1±0.1 g/cm3
Boiling Point	343.9±35.0 °C at 760 mmHg
Molecular Formula	C₁₁H₁₉NO₂
Molecular Weight	197.274
Flash Point	161.8±25.9 °C
Exact Mass	197.141586
PSA	49.33000
LogP	1.99
Appearance of Characters	lyophilized powder
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.517
Storage condition	−20°C

Streptokinase MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OB8880000

CHEMICAL NAME :: Kinase (enzyme-activating), strepto-

CAS REGISTRY NUMBER :: 9002-01-1

LAST UPDATED :: 199512

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 600 iu/kg

TOXIC EFFECTS :: Immunological Including Allergic - uncharacterized

REFERENCE :: JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 252,1314,1984

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 562500 iu/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 252,1314,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,671,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FOHEAW Folia Haematologica (Leipzig). (Buchexport, Postfach 160, Leipzig DDR-7010, Ger. Dem. Rep.) V.32- 1926- Volume(issue)/page/year: 103,445,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FOHEAW Folia Haematologica (Leipzig). (Buchexport, Postfach 160, Leipzig DDR-7010, Ger. Dem. Rep.) V.32- 1926- Volume(issue)/page/year: 103,445,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,671,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4087 No. of Facilities: 41 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 9366 (estimated) No. of Female Employees: 8266 (estimated)

Hazard Codes	C,Xi
Risk Phrases	36/37/38
Safety Phrases	22-24/25-36-26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	OB8880000

Staphylokinase, a fibrin-specific plasminogen activator with therapeutic potential?

Blood 84 , 680-6, (1994)

Primary coronary intervention versus thrombolytic therapy in myocardial infarction patients in the Middle East Al-Zakwani, I., et al.

J. Am. Med. Assoc. 34(3) , 445-51, (2012)

Effects of plasminogen and streptokinase on the vital functions of nervous tissue cells in culture Nikandrov, V., et al.

Biomed. Khim. 54 , 192-200, (2012)

L-Proline,4-cyclohexyl-,(4S)

MFCD00082037

Streptokinase

4-Cyclohexylproline

4-cyclohexyl-2-pyrrolidinecarboxylic acid

Proline, 4-cyclohexyl-

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DC Chemicals Limited
China
Product Name: Streptokinase
Price: $Inquiry/1g
Purity: 98.0%
Delivery: 1 Day
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Streptokinase

Use of Streptokinase

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Streptokinase Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Articles3

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.