Polyoxyethylene lauryl ether

Modify Date: 2024-01-02 11:57:38

Polyoxyethylene lauryl ether Structure
Polyoxyethylene lauryl ether structure
Common Name Polyoxyethylene lauryl ether
CAS Number 9002-92-0 Molecular Weight 1199.543
Density 1.1±0.1 g/cm3 Boiling Point 960.0±60.0 °C at 760 mmHg
Molecular Formula (C2H4O)nC12H26O Melting Point 41-45 °C(lit.)
MSDS Chinese USA Flash Point 534.4±32.9 °C
Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger

 Use of Polyoxyethylene lauryl ether


Polidocanol is a sclerosing agent used successfully to treat extremity and esophageal varices and telangiectasias.

 Names

Name Polyoxyethylene lauryl ether
Synonym More Synonyms

 Polyoxyethylene lauryl ether Biological Activity

Description Polidocanol is a sclerosing agent used successfully to treat extremity and esophageal varices and telangiectasias.
Related Catalog
In Vivo Polidocanol (0.5%, 1%, and 2%) results in significantly more adhesions than tetracycline, whereas the effect of diluted polidocanol is similar to that of tetracycline in rats. The higher concentrationsof polidocanol, of 0.5%, 1%, and 2% are more effective than either the diluted polidocanol or tetracycline against pleurodesis[1].
References

[1]. Cetin B, et al. Polidocanol at different concentrations for pleurodesis in rats. Surg Today. 2005;35(12):1066-9.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 960.0±60.0 °C at 760 mmHg
Melting Point 41-45 °C(lit.)
Molecular Formula (C2H4O)nC12H26O
Molecular Weight 1199.543
Flash Point 534.4±32.9 °C
Exact Mass 1198.801270
PSA 232.52000
LogP -2.83
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.465
Storage condition Store at RT.
Stability Stable. Combustible. Incompatible with strong oxidizing agents.

 MSDS

Name: BRIJ 35 30% w/v solution in water Material Safety Data Sheet
Synonym: None Known
CAS: 9002-92-0
Section 1 - Chemical Product MSDS Name:BRIJ 35 30% w/v solution in water Material Safety Data Sheet
Synonym:None Known

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
9002-92-0 BRIJ 35, 30% w/v solution in water unlisted
Hazard Symbols: None Listed.
Risk Phrases: None Listed.

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. May be harmful if swallowed.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. May be harmful if inhaled.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Use with adequate ventilation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 9002-92-0: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Liquid
Color: clear
Odor: Not available.
pH: 5-7
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: 235 deg F ( 112.78 deg C)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: Soluble.
Specific Gravity/Density: 1.03
Molecular Formula: Solution
Molecular Weight: 0

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 9002-92-0: JR5960000 JR5970000 JR5990000 MD0875000 LD50/LC50:
CAS# 9002-92-0: Draize test, rabbit, eye: 10 mg; Draize test, rabbit, eye: 100 mg; Draize test, rabbit, eye: 750 ug/24H Severe; Draize test, rabbit, skin: 100 mg; Draize test, rabbit, skin: 500 mg/24H Mild; Draize test, rabbit, skin: 75 mg/24H Mild; Draize test, rabbit, skin: 500 mg/24H Moderate; Oral, mouse: LD50 = 4940 mg/kg; Oral, mouse: LD50 = 1170 mg/kg; Oral, mouse: LD50 = 3500 mg/kg; Oral, mouse: LD50 = 1170 mg/kg; Oral, rat: LD50 = 8600 mg/kg; Oral, rat: LD50 = 4150 mg/kg; Oral, rat: LD50 = 8600 mg/kg; Oral, rat: LD50 = 1 gm/kg.
Carcinogenicity:
BRIJ 35, 30% w/v solution in water - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 9002-92-0: 2
Canada
CAS# 9002-92-0 is listed on Canada's DSL List.
CAS# 9002-92-0 is listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 9002-92-0 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
JR5990000
CHEMICAL NAME :
Dodecyl alcohol condensed with 23 moles ethylene oxide
CAS REGISTRY NUMBER :
9002-92-0
LAST UPDATED :
199710
DATA ITEMS CITED :
6
WISWESSER LINE NOTATION :
T3OTJ 23 &Q12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SPCOAH Soap, Perfumery & Cosmetics. (London, UK) V.8(7)-48(2), 1935-75. Volume(issue)/page/year: 38,47,1965
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APRCAS American Perfumer and Cosmetics. (Oak Park, IL) V.77-86, 1962-71. For publisher information, see CSPEAX. Volume(issue)/page/year: 77,35,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1179 No. of Facilities: 3288 (estimated) No. of Industries: 33 No. of Occupations: 37 No. of Employees: 43764 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1179 No. of Facilities: 5821 (estimated) No. of Industries: 32 No. of Occupations: 40 No. of Employees: 104035 (estimated) No. of Female Employees: 60645 (estimated)

 Safety Information

Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H302-H315-H318
Precautionary Statements P280-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R22;R36/37/38
Safety Phrases 26-39-37/39-36/37/39-36-24/25
RIDADR UN 3082 9/PG 3
WGK Germany 3
RTECS MD0875000
HS Code 34021300

 Customs

HS Code 34021300

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 Synonyms

depeg
EINECS 500-002-6
la7
g3711
ped
bl9
do9
g3707
polyoxethyleneglycol-23 lauryl ether
bl9ex
Polidocanol (PEG Monododecyl Ether)
yx500
AEO4
MFCD00080891
Brij 35
Polidocanol
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