2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-6,7-dimethoxy-quinolin-4-amine

Modify Date: 2024-01-12 12:10:06

2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-6,7-dimethoxy-quinolin-4-amine Structure
2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-6,7-dimethoxy-quinolin-4-amine structure
Common Name 2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-6,7-dimethoxy-quinolin-4-amine
CAS Number 90402-40-7 Molecular Weight 395.45200
Density 1.246g/cm3 Boiling Point 630.3ºC at 760mmHg
Molecular Formula C22H25N3O4 Melting Point N/A
MSDS N/A Flash Point 335ºC

 Use of 2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-6,7-dimethoxy-quinolin-4-amine


Abanoquil (U-K52046), an potent and selective α-1 adrenoceptor antagonist, is an anti-arrhythmic agent. Abanoquil can be used for erectile dysfunction research[1][2].

 Names

Name 2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-6,7-dimethoxyquinolin-4-amine
Synonym More Synonyms

  Biological Activity

Description Abanoquil (U-K52046), an potent and selective α-1 adrenoceptor antagonist, is an anti-arrhythmic agent. Abanoquil can be used for erectile dysfunction research[1][2].
Related Catalog
Target

α1-adrenergic receptor

In Vivo Abanoquil 在猴子模型体内注射时能够松弛收缩的组织条并诱导勃起反应[1]。
References

[1]. A Giraldi, et al. Abanoquil, a new alpha-1 adrenoceptor antagonist. In vitro and in vivo effect on erectile tissue. Int J Impot Res. 2000 Mar;12(S1):S37-S40.  

[2]. T C Tham, et al. Dose-dependent alpha 1-adrenoceptor antagonist activity of the anti-arrhythmic drug, abanoquil (UK-52,046), without reduction in blood pressure in man. Br J Clin Pharmacol. 1992 Apr;33(4):405-9.  

 Chemical & Physical Properties

Density 1.246g/cm3
Boiling Point 630.3ºC at 760mmHg
Molecular Formula C22H25N3O4
Molecular Weight 395.45200
Flash Point 335ºC
Exact Mass 395.18500
PSA 79.07000
LogP 4.06030

 Synonyms

4-amino-6,7-dimethoxy-2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinol-2-yl)quinoline
UNII-F738MWY53L
Abanoquil
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Price: ¥2500/5 mg

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