Ecamsule.2Na

Modify Date: 2024-01-09 17:19:13

Ecamsule.2Na Structure
Ecamsule.2Na structure
Common Name Ecamsule.2Na
CAS Number 90458-75-6 Molecular Weight 634.712
Density N/A Boiling Point N/A
Molecular Formula C30H36Na2O8S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Ecamsule.2Na


Ecamsule disodium is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression[1][2].

 Names

Name Disodium {1,4-phenylenebis[2-ethyl-1-ylidene(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl-3-ylidene)]}dimethanesulfonate
Synonym More Synonyms

 Ecamsule.2Na Biological Activity

Description Ecamsule disodium is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression[1][2].
Related Catalog
In Vitro Ecamsule is a broad-spectrum UVA-absorber with maximum absorbance at 344 nm[1]. Wild-type Fibs E6/E7 cells are more sensitive towards Ecamsule (200-1600 μM) treatment. In the fibroblasts, Ecamsule counteractes UV and AAPH induced ROS-formation. In addition, basal ROS levels are reduced. The effects are dose-dependent, reaching a maxi-mum ROS reduction by 25.7% at the highest tested concentration of 1600 μM in the UV-setting. With the same concentration of Ecamsule, oxidative stress that had been trigged by AAPH is reduced by 10.8% and basal levels are attenuated by 16.9%. Ecamsule increases the viability at the highest applied concentration of 1600 μM in the AAPH-treated cells[1].
References

[1]. Stefanie Hofer, et al. Contradictory effects of chemical filters in UV/ROS-stressed human keratinocyte and fibroblast cells. ALTEX. 2019;36(2):231-244.

[2]. Vincent A DeLeo, et al. A new ecamsule-containing SPF 40 sunscreen cream for the prevention of polymorphous light eruption: a double-blind, randomized, controlled study in maximized outdoor conditions. Cutis. 2009 Feb;83(2):95-103.

 Chemical & Physical Properties

Molecular Formula C30H36Na2O8S2
Molecular Weight 634.712
Exact Mass 634.164673

 Synonyms

Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 3,3'-(1,4-phenylenedi-2-ethyl-1-ylidene)bis[7,7-dimethyl-2-oxo-, sodium salt (1:2)
Disodium {1,4-phenylenebis[2-ethyl-1-ylidene(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl-3-ylidene)]}dimethanesulfonate
L55 A CVYTJ A1 A1 B1SWQ DU2R D2U- DL55 A CVYTJ A1 A1 B1SWQ &&2Na salt
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