thermolysin fromGeobacillus stearothermophilus
thermolysin fromGeobacillus stearothermophilus structure
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Common Name | thermolysin fromGeobacillus stearothermophilus | ||
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| CAS Number | 9073-78-3 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | N/A | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07, GHS08 |
Signal Word | Danger | |
Use of thermolysin fromGeobacillus stearothermophilusThermolysin is a thermostable neutral metalloproteinase enzyme secreted by the Gram-positive bacteria Bacillus thermoproteolyticus. Thermolysin catalyzes the hydrolysis of peptide bonds containing hydrophobic residues[1]. |
| Name | Thermolysin |
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| Synonym | More Synonyms |
| Description | Thermolysin is a thermostable neutral metalloproteinase enzyme secreted by the Gram-positive bacteria Bacillus thermoproteolyticus. Thermolysin catalyzes the hydrolysis of peptide bonds containing hydrophobic residues[1]. |
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| Related Catalog | |
| In Vitro | Thermolysin (100 μg in 1 mL, 64°C for 4 h, in isolated starch granules) digestion results in the selective removal of a group of low-molecular-mass proteins ranging between 10 and 27 kD[2]. Thermolysin can be used for the hydrolysis of bovine liver sarcoplasmic proteins[3]. |
| In Vivo | Thermolysin (50 mg/kg, p.o., once) lowers systolic blood pressure in SHR rats[4]. Thermolysin is not acutely toxic with an oral LD50 of more than 18000 mg/kg in rats and more than 24000 mg/kg in mice (Acute toxicity studies)[5]. Animal Model: Spontaneously hypertensive rats (SHR) rats[4] Dosage: 50 mg/kg Administration: Oral administration (p.o.), once Result: Lowered systolic blood pressure in SHR rats, with maximal reduction by 22 mm in systolic blood pressure being observed 6 h after administration. |
| Storage condition | 20°C |
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| Symbol |
GHS07, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H315-H317-H319-H334-H335 |
| Precautionary Statements | P261-P280-P305 + P351 + P338-P342 + P311 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn |
| Risk Phrases | 36/37/38-42/43 |
| Safety Phrases | 22-26-36/37 |
| RIDADR | NONH for all modes of transport |
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Enzymatic amine acyl exchange in peptides on gold surfaces.
Angew. Chem. Int. Ed. Engl. 51(52) , 13016-8, (2012) Reversible as well as stereo- and chemoselective: various proteases such as thermolysin and chymotrypsin catalyze amine acyl exchange in peptides. This acyl exchange can be used to modify amino-functi... |
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Local unfolding is required for the site-specific protein modification by transglutaminase.
Biochemistry 51 , 8679-8689, (2012) The transglutaminase (TGase) from Streptomyces mobaraensis catalyzes transamidation reactions in a protein substrate leading to the modification of the side chains of Gln and Lys residues according to... |
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Angiotensin-I converting enzyme inhibitory and antioxidant activities of egg protein hydrolysates produced with gastrointestinal and nongastrointestinal enzymes.
J. Food Sci. 76(6) , C801-7, (2011) Egg is a well-known rich source of bioactive peptides. In this study, egg protein (egg white and egg yolk proteins) hydrolysates were produced with gastrointestinal enzymes (pepsin and pancreatin) or ... |
| MFCD00165549 |