2-methyl-m-phenylene diisocyanate

Modify Date: 2026-07-05 16:42:11

2-methyl-m-phenylene diisocyanate structure	Common Name	2-methyl-m-phenylene diisocyanate
	CAS Number	91-08-7	Molecular Weight	174.15600
	Density	1.225 g/mL at 25 °C(lit.)	Boiling Point	129-133 °C18 mm Hg(lit.)
	Molecular Formula	C₉H₆N₂O₂	Melting Point	13°C
	MSDS	Chinese USA	Flash Point	>230 °F
	Symbol	GHS06, GHS08	Signal Word	Danger

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	toluene 2,6-diisocyanate
Synonym	More Synonyms

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.225 g/mL at 25 °C(lit.)
Boiling Point	129-133 °C18 mm Hg(lit.)
Melting Point	13°C
Molecular Formula	C₉H₆N₂O₂
Molecular Weight	174.15600
Flash Point	>230 °F
Exact Mass	174.04300
PSA	58.86000
LogP	1.92960
Index of Refraction	n20/D 1.571(lit.)
InChIKey	RUELTTOHQODFPA-UHFFFAOYSA-N
SMILES	Cc1c(N=C=O)cccc1N=C=O
Storage condition	−20°C
Stability	Stability Reacts violently with water. Reacts very rapidly with compounds containing an active hydrogen, such as amines, alcohols and acids. Polymerizes rapidly in the presence of base. Combustible. Incompatible with strong oxidizing agents.

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

2-methyl-m-phenylene diisocyanate MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ6310000

CHEMICAL NAME :: Benzene, 2,6-diisocyanato-1-methyl-

CAS REGISTRY NUMBER :: 91-08-7

BEILSTEIN REFERENCE NO. :: 2211546

LAST UPDATED :: 199710

DATA ITEMS CITED :: 20

MOLECULAR FORMULA :: C9-H6-N2-O2

MOLECULAR WEIGHT :: 174.17

WISWESSER LINE NOTATION :: OCNR B1 CNCO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human

DOSE/DURATION :: 50 ppb

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 300 mg/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 13,133,1989 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 39,287,1986 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 39,287,1986 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-DENMARK:TWA 0.005 ppm (0.035 mg/m3);Carcinogen JAN 1993 OEL-GERMANY:TWA 0.01 ppm (0.07 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 0.005 ppm (0.04 mg/m3);STEL 0.01 ppm JAN 1993 OEL-UNITED KINGDOM:TWA 0.02 mg/m3;STEL 0.07 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0788 No. of Facilities: 609 (estimated) No. of Industries: 14 No. of Occupations: 18 No. of Employees: 15830 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0788 No. of Facilities: 415 (estimated) No. of Industries: 12 No. of Occupations: 22 No. of Employees: 2872 (estimated) No. of Female Employees: 284 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS06, GHS08
Signal Word	Danger
Hazard Statements	H315-H317-H319-H330-H334-H335-H351-H412
Precautionary Statements	P260-P280-P284-P304 + P340 + P310-P342 + P311-P403 + P233
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	T+
Risk Phrases	26-36/37/38-40-42/43-52/53
Safety Phrases	S23-S36/37-S45-S61
RIDADR	UN 2078 6.1/PG 2
WGK Germany	2
RTECS	CZ6310000
Packaging Group	II
Hazard Class	6.1

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

phosgene

CAS#:75-44-5

2,6-diaminotoluene

CAS#:823-40-5

2,4-Diaminotoluene

CAS#:95-80-7

2-methyl-m-phen...

CAS#:91-08-7

Detail Learn More

Literature: WO2003/99770 A1, ; Page 7 ;

Obtucarbamate B

CAS#:20913-18-2

~99%

2-methyl-m-phen...

CAS#:91-08-7

Learn More

Literature: Valli, V. L. K.; Alper, H. Journal of Organic Chemistry, 1995 , vol. 60, # 1 p. 257 - 258

phosgene

CAS#:75-44-5

5-Methylbenzene...

CAS#:108-71-4

2,6-diaminotoluene

CAS#:823-40-5

2,4-Diaminotoluene

CAS#:95-80-7

2,5-Diaminotoluene

CAS#:95-70-5

Detail Learn More

Literature: EP1864969 A1, ; Page/Page column 5; 6 ;

phosgene

CAS#:75-44-5

2,6-diaminotoluene

CAS#:823-40-5

2-methyl-m-phen...

CAS#:91-08-7

Learn More

Literature: Justus Liebigs Annalen der Chemie, , vol. 562, p. 75,1114

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 6
CAS#:75-44-5 phosgene CAS#:823-40-5 2,6-diaminotoluene CAS#:95-80-7 2,4-Diaminotoluene CAS#:20913-18-2 Obtucarbamate B
CAS#:108-71-4 5-Methylbenzene... CAS#:95-70-5 2,5-Diaminotoluene
DownStream 2
CAS#:823-40-5 2,6-diaminotoluene CAS#:7440-44-0 Carbon

This table lists relevant public references with title, journal and publication metadata for this compound.

Biological monitoring as a valid tool to assess occupational exposure to mixtures of 2,4-:2,6-toluene diisocyanate.

Med. Lav. 103(5) , 361-71, (2012)

Despite its advantages over environmental monitoring, biological monitoring of exposure to 2,4-:2,6-toluene diisocyanate (TDI) mixtures is still underused. The present study was designed in order to e...

Magnetic field dependent electro-conductivity of the graphite doped magnetorheological plastomers.

Soft Matter 11 , 6893-902, (2015)

In this work we reported a novel graphite doped conductive magnetorheological plastomer (GMRP) with magnetic field dependent electro-conductivity. The conductivity of the GMRPs increased by increasing...

LC-MS determination of urinary toluenediamine in workers exposed to toluenediisocyanate.

Toxicol. Lett. 134(1-3) , 259-64, (2002)

To improve the biological monitoring method for 2,6- and 2,4-toluenediisocyanate (TDI) exposure, we developed a simple and rapid method for analysis of the corresponding urinary metabolites, 2,6- and ...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482

Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS ...
Source: 824
Target: N/A
External Id: P53MS837

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS898

Name: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
Source: NCGC
External Id: HERG01

Name: Adrenergic beta2 receptor (ADRB2) small molecule agonists, cell-based qHTS assay
Source: 824
External Id: ADRB2293

Total 209, Current Page 1 of 21

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

MFCD00002010

Tolylene 2,6-diisocyanate

2-METHYL-M-PHENYLENE DIISOCYANATE

EINECS 202-039-0

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What are the downstream products of toluene 2,6-diisocyanate?

A: Related downstream products(CAS) of toluene 2,6-diisocyanate: 823-40-5;7440-44-0.

Q: What is the CAS number of toluene 2,6-diisocyanate?

A: CAS number of toluene 2,6-diisocyanate is 91-08-7.

Q: What English synonyms does toluene 2,6-diisocyanate have?

A: English synonyms of toluene 2,6-diisocyanate: MFCD00002010, Tolylene 2,6-diisocyanate, 2-METHYL-M-PHENYLENE DIISOCYANATE, EINECS 202-039-0.

Q: What is the English name of toluene 2,6-diisocyanate?

A: The English name of toluene 2,6-diisocyanate is toluene 2,6-diisocyanate.

Q: What is the molecular weight of toluene 2,6-diisocyanate?

A: Molecular weight of toluene 2,6-diisocyanate is 174.15600.

Q: What is the melting point of toluene 2,6-diisocyanate?

A: Melting point of toluene 2,6-diisocyanate is 13°C.

Q: What is the LogP of toluene 2,6-diisocyanate?

A: LogP of toluene 2,6-diisocyanate is 1.92960.

Q: What are the upstream materials of toluene 2,6-diisocyanate?

A: Related upstream materials(CAS) of toluene 2,6-diisocyanate: 75-44-5;823-40-5;95-80-7;20913-18-2;108-71-4;95-70-5.

Q: What is the InChIKey of toluene 2,6-diisocyanate?

A: InChIKey of toluene 2,6-diisocyanate is RUELTTOHQODFPA-UHFFFAOYSA-N.

Q: What is the safety information for toluene 2,6-diisocyanate?

A: Safety information for toluene 2,6-diisocyanate: S23-S36/37-S45-S61.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Dayang Chem (Hangzhou) Co., Ltd.

Henan Tianfu Chemical Co., Ltd.

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-methyl-m-phenylene diisocyanate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Benzene, 1,3-diisocyanato-2-methyl-
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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2-methyl-m-phenylene diisocyanate

Names

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

Precursor & DownStream

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2-methyl-m-phenylene diisocyanateBioassay

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2-methyl-m-phenylene diisocyanate | FAQ

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