LAS101057

Modify Date: 2024-01-11 17:58:13

LAS101057 Structure
LAS101057 structure
Common Name LAS101057
CAS Number 925676-48-8 Molecular Weight 335.33500
Density 1.400±0.06 g/cm3 (20 °C, 760 mmHg) Boiling Point 509.2±50.0 °C (760 mmHg)
Molecular Formula C18H14FN5O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of LAS101057


LAS101057 is a potent, selective, and orally efficacious A2B receptor antagonist.

 Names

Name Cyclopropanecarboxamide, N-[5-(3-fluoro-4-pyridinyl)-6-(3-pyridinyl)-2-pyrazinyl]
Synonym More Synonyms

 LAS101057 Biological Activity

Description LAS101057 is a potent, selective, and orally efficacious A2B receptor antagonist.
Related Catalog
In Vivo At 3 mg/kg, LAS101057 is active in preventing methacholine-induced AHR, and at 10 mg/kg it inhibits AHR to methacholine to a level virtually equal to that seen with dexamethasone at 1 mg/kg[1].
References

[1]. Paul Eastwood, et al. Discovery of LAS101057: A Potent, Selective, and Orally Efficacious A2B Adenosine Receptor Antagonist. ACS Med Chem Lett. 2011 Mar 10; 2(3): 213-218.

 Chemical & Physical Properties

Density 1.400±0.06 g/cm3 (20 °C, 760 mmHg)
Boiling Point 509.2±50.0 °C (760 mmHg)
Molecular Formula C18H14FN5O
Molecular Weight 335.33500
Exact Mass 335.11800
PSA 80.66000
LogP 3.16120

 Synonyms

las-101057
LAS101057
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