DG70

Modify Date: 2024-04-11 08:54:37

DG70 Structure
DG70 structure
 Common Name DG70
CAS Number 930470-97-6 Molecular Weight 385.82
Density N/A Boiling Point N/A
Molecular Formula C21H17ClFNO3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DG70


DG70 (GSK1733953A), a biphenyl amide, is a respiration inhibitor in Mycobacterium tuberculosis, inhibits MenG activity with an IC50 value of 2.6 ± 0.6 μM. DG70 inhibits the catalytic methylation of Mycobacterium tuberculosis demethylmenaquinone methyltransferase enzymes. DG70 can be used for Tuberculosis (TB) research[1][2][3].

 Names

Name GSK1733953A

 DG70 Biological Activity

Description DG70 (GSK1733953A), a biphenyl amide, is a respiration inhibitor in Mycobacterium tuberculosis, inhibits MenG activity with an IC50 value of 2.6 ± 0.6 μM. DG70 inhibits the catalytic methylation of Mycobacterium tuberculosis demethylmenaquinone methyltransferase enzymes. DG70 can be used for Tuberculosis (TB) research[1][2][3].
Related Catalog
Target

IC50: 2.6 ± 0.6 μM (MenG)[1]

References

[1]. Pujari V, et al. Mycobacterial MenG: Partial Purification, Characterization, and Inhibition. ACS Infect Dis. 2022 Dec 9;8(12):2430-2440.  

[2]. Adewumi AT, et al. Thompson loop: opportunities for antitubercular drug design by targeting the weak spot in demethylmenaquinone methyltransferase protein. RSC Adv. 2020 Jun 19;10(39):23466-23483.  

[3]. Sukheja P, et al. A Novel Small-Molecule Inhibitor of the Mycobacterium tuberculosis Demethylmenaquinone Methyltransferase MenG Is Bactericidal to Both Growing and Nutritionally Deprived Persister Cells. mBio. 2017 Feb 14;8(1):e02022-16.  

 Chemical & Physical Properties

Molecular Formula C21H17ClFNO3
Molecular Weight 385.82
Storage condition 2-8°C
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Chemsrc provides DG70(CAS#:930470-97-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of DG70 are included as well.>> amp version: DG70

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