2-氯-N-{4',6-二甲氧基-[1,1'-联苯]-3-基}-4-氟苯甲酰胺

• 常用名: 2-氯-N-{4',6-二甲氧基-[1,1'-联苯]-3-基}-4-氟苯甲酰胺
• 英文名: DG70
• CAS号: 930470-97-6
• 分子量: 385.82
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₁₇ClFNO₃
• 熔点: N/A
• 闪点: N/A

用途

DG70 (GSK1733953A) 是一种联苯酰胺,是结核分枝杆菌的呼吸抑制剂,抑制 MenG 活性,IC50 值为 2.6 ± 0.6 μM。DG70抑制结核分枝杆菌去甲基萘醌甲基转移酶的催化甲基化。DG70可用于结核病(TB)研究。

名称

• 中文名: 2-氯-N-{4',6-二甲氧基-[1,1'-联苯]-3-基}-4-氟苯甲酰胺
• 英文名: GSK1733953A

生物活性

• 描述: DG70 (GSK1733953A) 是一种联苯酰胺,是结核分枝杆菌的呼吸抑制剂,抑制 MenG 活性,IC50 值为 2.6 ± 0.6 μM。DG70抑制结核分枝杆菌去甲基萘醌甲基转移酶的催化甲基化。DG70可用于结核病(TB)研究。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 靶点实验:

  IC50: 2.6 ± 0.6 μM (MenG)[1]

• 参考文献:

  [1]. Pujari V, et al. Mycobacterial MenG: Partial Purification, Characterization, and Inhibition. ACS Infect Dis. 2022 Dec 9;8(12):2430-2440.

  [2]. Adewumi AT, et al. Thompson loop: opportunities for antitubercular drug design by targeting the weak spot in demethylmenaquinone methyltransferase protein. RSC Adv. 2020 Jun 19;10(39):23466-23483.

  [3]. Sukheja P, et al. A Novel Small-Molecule Inhibitor of the Mycobacterium tuberculosis Demethylmenaquinone Methyltransferase MenG Is Bactericidal to Both Growing and Nutritionally Deprived Persister Cells. mBio. 2017 Feb 14;8(1):e02022-16.

物理化学性质

• 分子式: C₂₁H₁₇ClFNO₃
• 分子量: 385.82
• InChIKey: RWSCJEILSRMTEH-UHFFFAOYSA-N
• SMILES: COc1ccc(-c2cc(NC(=O)c3ccc(F)cc3Cl)ccc2OC)cc1
• 储存条件: 2-8°C

靶点实验

查看更多实验

实验名称：AntiMycobacterium tuberculosis activity day 21 in 7H9/2.5mM butyrate/pH6/0.1mM nitrit... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL3832775

实验名称：AntiMycobacterium tuberculosis activity day 10 in 7H9/2.5mM butyrate/pH6/0.1mM nitrit... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL3832776

实验名称：AntiMycobacterium tuberculosis activity day 21 MIC99 in 7H9/2.5mM butyrate/pH6/0.1mM ... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL3832777

实验名称：AntiMycobacterium tuberculosis activity 2-week 7H9/DPPC/cholesterol/BSA/Tx MIC (uM) 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL3832771

实验名称：AntiMycobacterium tuberculosis activity 1-week 7H9/cholesterol/BSA/Tx MIC (uM) 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL3832772

实验名称：AntiMycobacterium tuberculosis activity 2-week Alamar Blue 7H9/cholesterol/BSA/Tx MIC... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL3832773

实验名称：AntiMycobacterium tuberculosis activity day 10 in 7H9/2.5mM butyrate/pH6/0.1mM nitrit... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL3832774

实验名称：Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4296184

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：GSK_TB: GSK in-house hydrophobicity assay at pH7.4 (logD) 来源：ChEMBL 靶标：N/A External Id：CHEMBL2098497

共35条，当前第1页，共4页

1

2

3

4