5-HT3 antagonist 4

Modify Date: 2026-07-16 18:34:18

5-HT3 antagonist 4 Structure
5-HT3 antagonist 4 structure
Common Name 5-HT3 antagonist 4
CAS Number 930478-88-9 Molecular Weight 297.74
Density 1.4±0.1 g/cm3 Boiling Point 388.9±42.0 °C at 760 mmHg
Molecular Formula C16H12ClN3O Melting Point N/A
MSDS N/A Flash Point 189.0±27.9 °C

 Use of 5-HT3 antagonist 4


5-HT3 antagonist 4 is a 5-HT3 receptor (5HT3R) antagonist. 5-HT3 antagonist 4 prevents diabetes-induced depressive phenotypes in mice[1].

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name N-(3-Chloro-2-methylphenyl)-2-quinoxalinecarboxamide
Synonym More Synonyms

 5-HT3 antagonist 4 Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description 5-HT3 antagonist 4 is a 5-HT3 receptor (5HT3R) antagonist. 5-HT3 antagonist 4 prevents diabetes-induced depressive phenotypes in mice[1].
Related Catalog
References

[1]. Deepali Gupta, et al. A novel 5HT3 antagonist 4i (N-(3-chloro-2-methylphenyl)quinoxalin-2-carboxamide) prevents diabetes-induced depressive phenotypes in mice: Modulation of serotonergic system. Behav Brain Res. 2016 Jan 15;297:41-50.  

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.4±0.1 g/cm3
Boiling Point 388.9±42.0 °C at 760 mmHg
Molecular Formula C16H12ClN3O
Molecular Weight 297.74
Flash Point 189.0±27.9 °C
Exact Mass 297.066895
LogP 4.12
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.707
InChIKey SCIBFCFFUQXLCN-UHFFFAOYSA-N
SMILES Cc1c(Cl)cccc1NC(=O)c1cnc2ccccc2n1

 5-HT3 antagonist 4Bioassay

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This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Antidepressant-like activity in mouse assessed as immobility time at 2 mg/kg, ip by f...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL1273756
Name: Toxicity in mouse assessed as induction of spontaneous locomotor activity at 1 mg/kg,...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL1273757
Name: Toxicity in mouse assessed as induction of spontaneous locomotor activity at 0.5 mg/k...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL1273758
Name: Toxicity in mouse assessed as induction of spontaneous locomotor activity at 2 mg/kg,...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL1273759
Name: Antagonist activity 5-HT3A receptor in guinea pig ileum assessed as inhibition of 2-m...
Source: ChEMBL
Target: 5-hydroxytryptamine receptor 3A
External Id: CHEMBL4219564
Name: Antagonist activity at 5HT3 receptor in guinea pig ileum longitudinal muscle myenteri...
Source: ChEMBL
Target: 5-hydroxytryptamine receptor 3A
External Id: CHEMBL1273753
Name: Antidepressant-like activity in mouse assessed as immobility time at 1 mg/kg, ip by f...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL1273754
Name: Antidepressant-like activity in mouse assessed as immobility time at 0.5 mg/kg, ip by...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL1273755
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 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

N-(3-Chloro-2-methylphenyl)-2-quinoxalinecarboxamide

 5-HT3 antagonist 4 | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the LogP of N-(3-Chloro-2-methylphenyl)-2-quinoxalinecarboxamide?
A: LogP of N-(3-Chloro-2-methylphenyl)-2-quinoxalinecarboxamide is 4.12.
Q: What is the Chinese name of 930478-88-9?
A: Chinese name of 930478-88-9 is 930478-88-9.
Q: What is the molecular weight of N-(3-Chloro-2-methylphenyl)-2-quinoxalinecarboxamide?
A: Molecular weight of N-(3-Chloro-2-methylphenyl)-2-quinoxalinecarboxamide is 297.74.
Q: What is the InChIKey of N-(3-Chloro-2-methylphenyl)-2-quinoxalinecarboxamide?
A: InChIKey of N-(3-Chloro-2-methylphenyl)-2-quinoxalinecarboxamide is SCIBFCFFUQXLCN-UHFFFAOYSA-N.
Q: What is the molecular formula of N-(3-Chloro-2-methylphenyl)-2-quinoxalinecarboxamide?
A: Molecular formula of N-(3-Chloro-2-methylphenyl)-2-quinoxalinecarboxamide is C16H12ClN3O.
Q: What are the uses of N-(3-Chloro-2-methylphenyl)-2-quinoxalinecarboxamide?
A: Main uses of N-(3-Chloro-2-methylphenyl)-2-quinoxalinecarboxamide: 5-HT3 antagonist 4 is a 5-HT3 receptor (5HT3R) antagonist. 5-HT3 antagonist 4 prevents diabetes-induced depressive phenotypes in mice[1].
Q: What is the boiling point of N-(3-Chloro-2-methylphenyl)-2-quinoxalinecarboxamide?
A: Boiling point of N-(3-Chloro-2-methylphenyl)-2-quinoxalinecarboxamide is 388.9±42.0 °C at 760 mmHg.
Q: What English synonyms does N-(3-Chloro-2-methylphenyl)-2-quinoxalinecarboxamide have?
A: English synonyms of N-(3-Chloro-2-methylphenyl)-2-quinoxalinecarboxamide: N-(3-Chloro-2-methylphenyl)-2-quinoxalinecarboxamide.
Q: What is the SMILES notation of N-(3-Chloro-2-methylphenyl)-2-quinoxalinecarboxamide?
A: SMILES notation of N-(3-Chloro-2-methylphenyl)-2-quinoxalinecarboxamide is Cc1c(Cl)cccc1NC(=O)c1cnc2ccccc2n1.
Q: What is the CAS number of N-(3-Chloro-2-methylphenyl)-2-quinoxalinecarboxamide?
A: CAS number of N-(3-Chloro-2-methylphenyl)-2-quinoxalinecarboxamide is 930478-88-9.

 5-HT3 antagonist 4factory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

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