5-HT3 antagonist 4

• 常用名: 5-HT3 antagonist 4
• 英文名: 5-HT3 antagonist 4
• CAS号: 930478-88-9
• 分子量: 297.74
• 密度: 1.4±0.1 g/cm3
• 沸点: 388.9±42.0 °C at 760 mmHg
• 分子式: C₁₆H₁₂ClN₃O
• 熔点: N/A
• 闪点: 189.0±27.9 °C

5-HT3 antagonist 4用途

5-HT3拮抗剂4是5-HT3受体(5HT3R)拮抗剂。5-HT3拮抗剂4可预防糖尿病诱导的小鼠抑郁表型[1]。

5-HT3 antagonist 4名称

• 英文名: N-(3-Chloro-2-methylphenyl)-2-quinoxalinecarboxamide

5-HT3 antagonist 4生物活性

• 描述: 5-HT3拮抗剂4是5-HT3受体(5HT3R)拮抗剂。5-HT3拮抗剂4可预防糖尿病诱导的小鼠抑郁表型[1]。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
• 体内研究: 5-HT3拮抗剂 4(4i)(0.5和 1mg/kg/天,腹腔注射；持续 4.周)可改善糖尿病小鼠的糖尿病诱发的抑郁样行为和血清素缺乏[1]
• 参考文献:

  [1]. Deepali Gupta, et al. A novel 5HT3 antagonist 4i (N-(3-chloro-2-methylphenyl)quinoxalin-2-carboxamide) prevents diabetes-induced depressive phenotypes in mice: Modulation of serotonergic system. Behav Brain Res. 2016 Jan 15;297:41-50.

5-HT3 antagonist 4物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 388.9±42.0 °C at 760 mmHg
• 分子式: C₁₆H₁₂ClN₃O
• 分子量: 297.74
• 闪点: 189.0±27.9 °C
• 精确质量: 297.066895
• LogP: 4.12
• InChIKey: SCIBFCFFUQXLCN-UHFFFAOYSA-N
• SMILES: Cc1c(Cl)cccc1NC(=O)c1cnc2ccccc2n1
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.707

5-HT3 antagonist 4靶点实验

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实验名称：Antidepressant-like activity in mouse assessed as immobility time at 2 mg/kg, ip by f... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1273756

实验名称：Toxicity in mouse assessed as induction of spontaneous locomotor activity at 1 mg/kg,... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1273757

实验名称：Toxicity in mouse assessed as induction of spontaneous locomotor activity at 0.5 mg/k... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1273758

实验名称：Toxicity in mouse assessed as induction of spontaneous locomotor activity at 2 mg/kg,... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1273759

实验名称：Antagonist activity 5-HT3A receptor in guinea pig ileum assessed as inhibition of 2-m... 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 3A External Id：CHEMBL4219564

实验名称：Antagonist activity at 5HT3 receptor in guinea pig ileum longitudinal muscle myenteri... 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 3A External Id：CHEMBL1273753

实验名称：Antidepressant-like activity in mouse assessed as immobility time at 1 mg/kg, ip by f... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1273754

实验名称：Antidepressant-like activity in mouse assessed as immobility time at 0.5 mg/kg, ip by... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1273755

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5-HT3 antagonist 4英文别名

• N-(3-Chloro-2-methylphenyl)-2-quinoxalinecarboxamide