6-Azathymine

Modify Date: 2025-08-25 08:55:19

6-Azathymine structure	Common Name	6-Azathymine
	CAS Number	932-53-6	Molecular Weight	127.101
	Density	1.7±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₄H₅N₃O₂	Melting Point	210-212°C
	MSDS	N/A	Flash Point	N/A

Use of 6-Azathymine

6-Azathymine, a 6-nitrogen analog of thymine, is a potent D-3-aminoisobutyrate-pyruvate aminotransferase inhibitor. 6-Azathymine inhibits the biosynthesis of DNA, and has antibacterial and antiviral activities[1][2][3][4].

Name	6-methyl-2H-1,2,4-triazine-3,5-dione
Synonym	More Synonyms

Description	6-Azathymine, a 6-nitrogen analog of thymine, is a potent D-3-aminoisobutyrate-pyruvate aminotransferase inhibitor. 6-Azathymine inhibits the biosynthesis of DNA, and has antibacterial and antiviral activities[1][2][3][4].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	6-Azathymine is a competitive antagonist of the growth of Streptococcus faecalis (8043) and several other strains of microorganisms. Studies of the mechanism of action of 6-Azathymine reveal that S. faecalis can convert the analog to the corresponding deoxyriboside, azathymidine[2].
References	[1]. N Tamaki, et al. Purification, Characterization and Inhibition of D-3-aminoisobutyrate Aminotransferase From the Rat Liver. Eur J Biochem. 1990 Apr 20;189(1):39-45. [2]. W H PRUSOFF, et al. Effect of the Deoxyriboside of 6-azathymine (Azathymidine) on the Biosynthesis of Deoxyribonucleic Acid by Bone Marrow and Neoplastic Cells (In Vitro). Biochim Biophys Acta. 1956 Apr;20(1):209-14. [3]. R A GAITO, et al. Studies on the Metabolism of Thymine and 6-azathymine. Biochem Pharmacol. Apr-May 1962;11:323-36. [4]. B. Gabrielsen, et al. In vitro and in vivo antiviral (RNA) evaluation of orotidine 51-monophosphatedecarboxylase inhibitors and analogues including 6-azauridine-51-(ethylmethoxyalaninyl)phosphate (a 51-monophosphate prodrug). Antiviral Chemistry & Chemotherapy (1994) 5(4), 209-220.

Density	1.7±0.1 g/cm3
Melting Point	210-212°C
Molecular Formula	C₄H₅N₃O₂
Molecular Weight	127.101
Exact Mass	127.038177
PSA	78.61000
LogP	-2.05
Index of Refraction	1.692
InChIKey	XZWMZFQOHTWGQE-UHFFFAOYSA-N
SMILES	Cc1n[nH]c(=O)[nH]c1=O

6-Azathymine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XY8050000

CHEMICAL NAME :: as-Triazine-3,5(2H,4H)-dione, 6-methyl-

CAS REGISTRY NUMBER :: 932-53-6

LAST UPDATED :: 199012

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C4-H5-N3-O2

MOLECULAR WEIGHT :: 127.12

WISWESSER LINE NOTATION :: T6NMVMVJ F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage)

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 95,123,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

Safety Phrases	S22-S24/25
RTECS	XY8050000
HS Code	2933699090

6-AZA-2-THIOTHYMINE

CAS#:615-76-9

~79%

6-Azathymine

CAS#:932-53-6

Literature: Koegler, Martin; Busson, Roger; De Jonghe, Steven; Rozenski, Jef; Van Belle, Kristien; Louat, Thierry; Munier-Lehmann, Helne; Herdewijn, Piet Chemistry and Biodiversity, 2012 , vol. 9, # 3 p. 536 - 556

AI3-51930

CAS#:2704-30-5

6-Azathymine

CAS#:932-53-6

Literature: Monatshefte fur Chemie, , vol. 139, # 12 p. 1483 - 1490

Precursor 2
CAS#:615-76-9 6-AZA-2-THIOTHYMINE CAS#:2704-30-5 AI3-51930
DownStream 3
CAS#:13410-30-5 2-(2-Deoxy-beta... CAS#:61959-18-0 2-benzyl-6-meth... CAS#:55846-36-1 6-methyl-1,2,4-...

HS Code	2933699090
Summary	2933699090 other compounds containing an unfused triazine ring (whether or not hydrogenated) in the structure。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0%

Name: Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: HCMV UL50
External Id: HMS1262

Name: Screen for inhibitors of RMI FANCM (MM2) intereaction
Source: 11908
Target: N/A
External Id: RMI-FANCM-MM2

Name: Chemical Probes of Kaposi's Sarcoma Herpes Virus Latent Infection
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: ORF 73 [Human herpesvirus 8 type M]
External Id: HMS791

Name: NCI human tumor cell line growth inhibition assay. Data for the MCF7 Non-Small Cell L...
Source: DTP/NCI
Target: N/A
External Id: MCF7_OneDose

Name: qHTS for Inhibitors of Polymerase Kappa
Source: NCGC
Target: DNA polymerase kappa [Homo sapiens]
External Id: PolK100

Name: Vibrio cholerae assay for pro-quorum sensing small molecules
Source: Southern Research Specialized Biocontainment Screening Center
Target: cyclic AMP receptor protein [Vibrio cholerae O1 biovar El Tor str. N16961]
External Id: Vcholera_QS_Pilot

Name: Contractile Force Screening of Prestwick Library for asthma drug discovery
Source: 24015
Target: N/A
External Id: HSPH_Screening_CFS_001

Name: qHTS for Inhibitors of binding or entry into cells for Marburg Virus
Source: NCGC
Target: gene 4 small orf - Marburg virus
External Id: VSVM-OFFLINE

Name: A screen for compounds that inhibit viral RNA polymerase binding and polymerization a...
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: Chain A, Poliovirus Polymerase With Gtp
External Id: HMS750

Name: qHTS for Inhibitors of binding or entry into cells for Lassa Virus
Source: NCGC
Target: N/A
External Id: VSVL-OFFLINE

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6-Methyl-2H-[1,2,4]triazin-3,5-dion

USAF CB-28

Azathymine

6-methyl-2H-[1,2,4]triazine-3,5-dione

Azathymine,6

6-azathymine

1,2,4-Triazine-3,5(2H,4H)-dione,6-methyl

6-methyl-2H-[1,2,4]triazin-3,5-dione

6-methyl-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione

6-Methyl-1,2,4-triazine-3,5(2H,4H)-dione

6-methyl-1,2,4-triazine-3,5-diol

5-Methyl-6-azauracil

MFCD00006457

EINECS 213-253-9

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China
Product Name: 6-Azathymine
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1,2,4-Triazine-3,5(2H,4H)-dione,6-methyl-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 6-Azathymine
Price: ￥458.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Liu jia
Email: 2130147988@qq.com

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Price: ￥750/100 mg

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6-Azathymine

Use of 6-Azathymine

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6-Azathymine Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Synthetic Route

Precursor & DownStream

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6-AzathymineBioassay

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