CCI-007
Modify Date: 2024-08-12 19:06:18
CCI-007 structure
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Common Name | CCI-007 | ||
|---|---|---|---|---|
| CAS Number | 939228-52-1 | Molecular Weight | 336.362 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H16N2O5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CCI-007CCI-007 (CCI 007) is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia with IC50 of 3.5 uM against MLL-r leukemia cell line PER-485; induced a rapid caspase-dependent apoptosis with mitochondrial depolarization within 24h treatment; altered the characteristic MLL-r gene expression signature in sensitive cells with downregulation of the expression of HOXA9, MEIS1, CMYC and BCL2, important drivers in MLL-r leukemia. |
| Name | CCI-007 |
|---|
| Description | CCI-007 (CCI 007) is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia with IC50 of 3.5 uM against MLL-r leukemia cell line PER-485; induced a rapid caspase-dependent apoptosis with mitochondrial depolarization within 24h treatment; altered the characteristic MLL-r gene expression signature in sensitive cells with downregulation of the expression of HOXA9, MEIS1, CMYC and BCL2, important drivers in MLL-r leukemia. |
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| References | References 1. Somers K, et al. Oncotarget. 2016 Jul 19;7(29):46067-46087. View Related Products by Target Other Targets |
| Molecular Formula | C15H16N2O5S |
|---|---|
| Molecular Weight | 336.362 |
| InChIKey | KGSKTLMBOLPOTC-KPKJPENVSA-N |
| SMILES | CCOC(=O)COc1ccc(C=C2SC(=N)NC2=O)cc1OC |