939228-52-1
939228-52-1 structure
- Name: CCI-007
- Chemical Name: CCI-007
- CAS Number: 939228-52-1
- Molecular Formula: C15H16N2O5S
- Molecular Weight: 336.362
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2020-01-20 01:33:57
- Modify Date: 2023-10-18 16:56:17
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CCI-007 (CCI 007) is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia with IC50 of 3.5 uM against MLL-r leukemia cell line PER-485; induced a rapid caspase-dependent apoptosis with mitochondrial depolarization within 24h treatment; altered the characteristic MLL-r gene expression signature in sensitive cells with downregulation of the expression of HOXA9, MEIS1, CMYC and BCL2, important drivers in MLL-r leukemia.
| Name | CCI-007 |
|---|
| Description | CCI-007 (CCI 007) is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia with IC50 of 3.5 uM against MLL-r leukemia cell line PER-485; induced a rapid caspase-dependent apoptosis with mitochondrial depolarization within 24h treatment; altered the characteristic MLL-r gene expression signature in sensitive cells with downregulation of the expression of HOXA9, MEIS1, CMYC and BCL2, important drivers in MLL-r leukemia. |
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| References | References 1. Somers K, et al. Oncotarget. 2016 Jul 19;7(29):46067-46087. View Related Products by Target Other Targets |
| Molecular Formula | C15H16N2O5S |
|---|---|
| Molecular Weight | 336.362 |