SMER18
Modify Date: 2024-01-08 18:26:20
SMER18 structure
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Common Name | SMER18 | ||
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| CAS Number | 944153-47-3 | Molecular Weight | 287.741 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 458.7±45.0 °C at 760 mmHg | |
| Molecular Formula | C16H14ClNO2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 231.2±28.7 °C | |
Use of SMER18SMER18 is a small molecule enhancer of rapamycin which act as a mTOR-independent autophagy inducer.Target: mTORSMER18 induces autophagy independently of Rapamycin in mammalian cells, enhancing the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein, which are associated with Huntington's disease and familial Parkinson's disease, respectively. SMER18 acts either independently or downstream of the target of Rapamycin, attenuates mutant huntingtin-fragment toxicity in Huntington's disease cell and Drosophila melanogaster models, which suggests therapeutic potential. |
| Name | SMER18 |
|---|---|
| Synonym | More Synonyms |
| Description | SMER18 is a small molecule enhancer of rapamycin which act as a mTOR-independent autophagy inducer.Target: mTORSMER18 induces autophagy independently of Rapamycin in mammalian cells, enhancing the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein, which are associated with Huntington's disease and familial Parkinson's disease, respectively. SMER18 acts either independently or downstream of the target of Rapamycin, attenuates mutant huntingtin-fragment toxicity in Huntington's disease cell and Drosophila melanogaster models, which suggests therapeutic potential. |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 458.7±45.0 °C at 760 mmHg |
| Molecular Formula | C16H14ClNO2 |
| Molecular Weight | 287.741 |
| Flash Point | 231.2±28.7 °C |
| Exact Mass | 287.071320 |
| LogP | 3.88 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.656 |
| Storage condition | 2-8℃ |
| (2Z)-1-(4-Chlorophenyl)-3-[(3-hydroxyphenyl)amino]-2-buten-1-one |
| (2Z)-1-(4-Chlorophenyl)-3-[(3-hydroxyphenyl)amino]but-2-en-1-one |
| 2-Buten-1-one, 1-(4-chlorophenyl)-3-[(3-hydroxyphenyl)amino]-, (2Z)- |