SMER18

• 常用名: SMER18
• 英文名: SMER18
• CAS号: 944153-47-3
• 分子量: 287.741
• 密度: 1.3±0.1 g/cm3
• 沸点: 458.7±45.0 °C at 760 mmHg
• 分子式: C₁₆H₁₄ClNO₂
• 熔点: N/A
• 闪点: 231.2±28.7 °C

SMER18用途

SMER18是Rapamycin的一种小分子增强剂, 充当mTOR非依赖性的的自噬诱导剂。

SMER18名称

• 中文名: SMER18
• 英文名: SMER18

SMER18生物活性

• 描述: SMER18是Rapamycin的一种小分子增强剂, 充当mTOR非依赖性的的自噬诱导剂。
• 相关类别:
  信号通路 >> 自噬 >> 自噬
  研究领域 >> 癌症
• 参考文献:

  [1]. Sarkar S, et al. Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol. 2007 Jun;3(6):331-338.

SMER18物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 458.7±45.0 °C at 760 mmHg
• 分子式: C₁₆H₁₄ClNO₂
• 分子量: 287.741
• 闪点: 231.2±28.7 °C
• 精确质量: 287.071320
• LogP: 3.88
• InChIKey: SNEQASFEVWLKOJ-LUAWRHEFSA-N
• SMILES: CC(=CC(=O)c1ccc(Cl)cc1)Nc1cccc(O)c1
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.656
• 储存条件: 2-8℃

SMER18靶点实验

查看更多实验

实验名称：Enhancement of rapamycin-mediated cytostatic effect in Saccharomyces paradoxus after ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1243649

实验名称：Enhancement of rapamycin-mediated cytostatic effect in Saccharomyces mikatae after 48... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1243647

实验名称：Enhancement of rapamycin-mediated cytostatic effect in Saccharomyces bayanus after 48... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1243645

实验名称：Enhancement of autophagy in rat PC12 cells assessed as decrease in alpha-synuclein A5... 来源：ChEMBL 靶标：PC-12 External Id：CHEMBL1243658

实验名称：Enhancement of autophagy in rat PC12 cells assessed as decrease in alpha-synuclein A5... 来源：ChEMBL 靶标：PC-12 External Id：CHEMBL1243656

实验名称：Enhancement of autophagy in rat PC12 cells assessed as decrease in alpha-synuclein A5... 来源：ChEMBL 靶标：PC-12 External Id：CHEMBL1243655

实验名称：Inhibition of EGFP-tagged huntingtin aggregation expressed in african green monkey CO... 来源：ChEMBL 靶标：Huntingtin External Id：CHEMBL1243429

实验名称：Cytotoxicity against african green monkey COS7 cells at 43 uM after 24 hrs by FACS an... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1243427

实验名称：GPR151 activator identification: cell-based high-throughput counter-screen assay 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Glucose-dependent insulinotropic receptor; AltName: Full=G-protein coupled receptor 119 External Id：GPR119_PHUNTER_AG_LUMI_1536_3X%ACT CSRUN1

实验名称：Enhancement of autophagy in rat PC12 cells assessed as decrease in alpha-synuclein A5... 来源：ChEMBL 靶标：PC-12 External Id：CHEMBL1243425

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SMER18英文别名

• (2Z)-1-(4-Chlorophenyl)-3-[(3-hydroxyphenyl)amino]-2-buten-1-one
• (2Z)-1-(4-Chlorophenyl)-3-[(3-hydroxyphenyl)amino]but-2-en-1-one