Aumitin

Modify Date: 2025-09-10 19:28:19

Aumitin Structure
Aumitin structure
Common Name Aumitin
CAS Number 946293-78-3 Molecular Weight 429.90
Density N/A Boiling Point N/A
Molecular Formula C24H20ClN5O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Aumitin


Aumitin is a diaminopyrimidine-based autophagy inhibitor which inhibits mitochondrial respiration by targeting complex I. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC50s of 0.12 μM and 0.24 μM, respectively[1].

 Names

Name Aumitin

 Aumitin Biological Activity

Description Aumitin is a diaminopyrimidine-based autophagy inhibitor which inhibits mitochondrial respiration by targeting complex I. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC50s of 0.12 μM and 0.24 μM, respectively[1].
Related Catalog
References

[1]. Robke L, et al. Discovery of the novel autophagy inhibitor aumitin that targets mitochondrial complex I. Chem Sci. 2018 Feb 26;9(11):3014-3022.

 Chemical & Physical Properties

Molecular Formula C24H20ClN5O
Molecular Weight 429.90
InChIKey VJNNQBDSUIVCKB-UHFFFAOYSA-N
SMILES Cc1cc(Nc2ccccc2)nc(Nc2ccc(NC(=O)c3ccccc3Cl)cc2)n1
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