MNI 137

Modify Date: 2024-04-09 11:58:33

MNI 137 Structure
MNI 137 structure
Common Name MNI 137
CAS Number 946619-21-2 Molecular Weight 341.16200
Density 1.62±0.1 g/cm3 (20 °C, 760 mmHg) Boiling Point 561.2±50.0 °C (760 mmHg)
Molecular Formula C15H9BrN4O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MNI 137


MNI137 is a potent and selective negative allosteric modulator for group II mGluRs. MNI137 has IC50s values of 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization[1].

 Names

Name 2-Pyridinecarbonitrile, 4-(8-bromo-2,3-dihydro-2-oxo-1H-1,5-benzodiazepin-4-yl)
Synonym More Synonyms

 MNI 137 Biological Activity

Description MNI137 is a potent and selective negative allosteric modulator for group II mGluRs. MNI137 has IC50s values of 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization[1].
Related Catalog
References

[1]. Hemstapat K, et al. A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors. J Pharmacol Exp Ther. 2007;322(1):254-264.

 Chemical & Physical Properties

Density 1.62±0.1 g/cm3 (20 °C, 760 mmHg)
Boiling Point 561.2±50.0 °C (760 mmHg)
Molecular Formula C15H9BrN4O
Molecular Weight 341.16200
Exact Mass 339.99600
PSA 78.14000
LogP 2.75238

 Synonyms

MNI 137
VU 0360172 hydrochloride
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