BMS-751324
Modify Date: 2025-09-20 17:27:11
BMS-751324 structure
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Common Name | BMS-751324 | ||
|---|---|---|---|---|
| CAS Number | 948842-66-8 | Molecular Weight | 694.628 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C32H35N6O10P | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BMS-751324BMS-751324 is a novel clinical prodrug of BMS-582949, which is a highly selective p38α MAPK inhibitor with IC50 of 13 nM; BMS-751324 is effectively bioconverted into parent drug BMS-582949 in vivo by alkaline phosphatase and esterase in a stepwise manner; demonstrates similar efficacy in rat LPS-induced TNFα pharmacodynamic model and rat adjuvant arthritis model compared with BMS-582949; BMS-751324 is indeed effective in addressing the pH-dependent absorption issue associated with BMS-582949. |
| Name | Bms-751324 |
|---|---|
| Synonym | More Synonyms |
| Description | BMS-751324 is a novel clinical prodrug of BMS-582949, which is a highly selective p38α MAPK inhibitor with IC50 of 13 nM; BMS-751324 is effectively bioconverted into parent drug BMS-582949 in vivo by alkaline phosphatase and esterase in a stepwise manner; demonstrates similar efficacy in rat LPS-induced TNFα pharmacodynamic model and rat adjuvant arthritis model compared with BMS-582949; BMS-751324 is indeed effective in addressing the pH-dependent absorption issue associated with BMS-582949. |
|---|---|
| References | References 1. Liu C, et al. J Med Chem. 2015 Oct 8;58(19):7775-84. View Related Products by Target p38 MAPK |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C32H35N6O10P |
| Molecular Weight | 694.628 |
| Exact Mass | 694.215210 |
| LogP | 1.22 |
| Index of Refraction | 1.676 |
| InChIKey | XAYQDTPEOFCYIG-UHFFFAOYSA-N |
| SMILES | CCCN(C(=O)OCOC(=O)Cc1ccc(OP(=O)(O)O)cc1)C(=O)c1cn2ncnc(Nc3cc(C(=O)NC4CC4)ccc3C)c2c1C |
| Benzeneacetic acid, 4-(phosphonooxy)-, α-[[[[[[4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbonyl]propylamino]carbonyl]oxy]methyl] ester |
| Bms-751324 |
| ({[(4-{[5-(Cyclopropylcarbamoyl)-2-methylphenyl]amino}-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbonyl](propyl)carbamoyl}oxy)methyl [4-(phosphonooxy)phenyl]acetate |