TRO 40303
Modify Date: 2024-04-06 08:02:43
TRO 40303 structure
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Common Name | TRO 40303 | ||
|---|---|---|---|---|
| CAS Number | 949080-24-4 | Molecular Weight | 405.657 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 514.4±23.0 °C at 760 mmHg | |
| Molecular Formula | C26H47NO2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 344.4±11.9 °C | |
Use of TRO 40303TRO 40303 is a novel cardioprotective compound that delays mitochondrial permeability transition pore (mPTP) opening, binds specifically to TSPO at the cholesterol site (Ki=150 nM); has no effect on the calcium retention capacity (CRC) of isolated mitochondria; causes significant reduction in reactive oxygen species production and subsequent calcium overload; reduces infarct size when administered before reperfusion in in vivo model. |
| Name | TRO-40303 |
|---|---|
| Synonym | More Synonyms |
| Description | TRO 40303 is a novel cardioprotective compound that delays mitochondrial permeability transition pore (mPTP) opening, binds specifically to TSPO at the cholesterol site (Ki=150 nM); has no effect on the calcium retention capacity (CRC) of isolated mitochondria; causes significant reduction in reactive oxygen species production and subsequent calcium overload; reduces infarct size when administered before reperfusion in in vivo model. |
|---|---|
| References | References 1. Schaller S, et al. J Pharmacol Exp Ther. 2010 Jun;333(3):696-706. 2. Le Lamer S, et al. J Transl Med. 2014 Feb 7;12:38. 3. Hansson MJ, et al. Eur J Pharmacol. 2015 Aug 5;760:7-19. View Related Products by Target Mitochondrial Permeability Transition Pore (mPTP) |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 514.4±23.0 °C at 760 mmHg |
| Molecular Formula | C26H47NO2 |
| Molecular Weight | 405.657 |
| Flash Point | 344.4±11.9 °C |
| Exact Mass | 405.360687 |
| LogP | 8.23 |
| Vapour Pressure | 0.0±3.0 mmHg at 25°C |
| Index of Refraction | 1.558 |
| TRO-40303 |
| 7H-Benz[e]inden-7-one, 3-[(1R)-1,5-dimethylhexyl]dodecahydro-6-(3-hydroxypropyl)-3a,6-dimethyl-, oxime, (3R,3aR,5aS,6R,7E,9aS,9bS)- |
| 3W389841RN |
| 3-{(3R,3aR,5aS,6R,7E,9aS,9bS)-7-(Hydroxyimino)-3a,6-dimethyl-3-[(2R)-6-methyl-2-heptanyl]dodecahydro-1H-cyclopenta[a]naphthalen-6-yl}-1-propanol |