Methidathion

Modify Date: 2024-01-02 20:05:11

Methidathion Structure
Methidathion structure
Common Name Methidathion
CAS Number 950-37-8 Molecular Weight 302.331
Density 1.6±0.1 g/cm3 Boiling Point 347.7±52.0 °C at 760 mmHg
Molecular Formula C6H11N2O4PS3 Melting Point 39-40°C
MSDS Chinese USA Flash Point 164.1±30.7 °C
Symbol GHS05 GHS06 GHS09
GHS05, GHS06, GHS09
Signal Word Danger

 Names

Name methidathion
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 347.7±52.0 °C at 760 mmHg
Melting Point 39-40°C
Molecular Formula C6H11N2O4PS3
Molecular Weight 302.331
Flash Point 164.1±30.7 °C
Exact Mass 301.961853
PSA 158.02000
LogP 2.03
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.652
Storage condition 0-6°C
Water Solubility 0.024 g/100 mL

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TE2100000
CHEMICAL NAME :
Phosphorodithioic acid, O,O-dimethyl ester, S-ester with 4-(mercaptomethyl)-2-methoxy- delta(sup 2)-1,3,4-thiadiazolin-5-one
CAS REGISTRY NUMBER :
950-37-8
LAST UPDATED :
199706
DATA ITEMS CITED :
20
MOLECULAR FORMULA :
C6-H11-N2-O4-P-S3
MOLECULAR WEIGHT :
302.34
WISWESSER LINE NOTATION :
T5NNVSJ B1SPS&O1&O1 EO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
CIGET* Ciba-Geigy Toxicology Data/Indexes. (Ciba-Geigy Corp., 556 Morris Ave., Summit, NJ 07901) ** ACUTE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
93 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - miosis (pupillary constriction) Sense Organs and Special Senses (Eye) - lacrimation Behavioral - coma
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
50 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CIGET* Ciba-Geigy Toxicology Data/Indexes. (Ciba-Geigy Corp., 556 Morris Ave., Summit, NJ 07901)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
63 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
196 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CIGET* Ciba-Geigy Toxicology Data/Indexes. (Ciba-Geigy Corp., 556 Morris Ave., Summit, NJ 07901)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
80 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
225 mg/kg/9W-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
17155 mg/kg/1Y-I
TOXIC EFFECTS :
Liver - jaundice, cholestatic Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
40 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 88,307,1981 *** REVIEWS *** TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 46,1,1973 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 63,1,1976 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2166 No. of Facilities: 13 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 26 (estimated)

 Safety Information

Symbol GHS05 GHS06 GHS09
GHS05, GHS06, GHS09
Signal Word Danger
Hazard Statements H300 + H310 + H330-H318-H410
Precautionary Statements P260-P264-P273-P280-P284-P301 + P310
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes T+:Verytoxic;N:Dangerous for the environment;
Risk Phrases R21;R28;R50/53
Safety Phrases S22-S28-S36/37-S45-S60-S61
RIDADR UN 2811
RTECS TE2100000
Packaging Group II
Hazard Class 6.1(a)

 Synthetic Route

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Methidathion Structure

Methidathion

CAS#:950-37-8

Literature: Helvetica chimica acta, , vol. 51, # 3 p. 518 - 526

~%

Methidathion Structure

Methidathion

CAS#:950-37-8

Literature: Helvetica Chimica Acta, , vol. 57, p. 1658 - 1675

 Articles28

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Aquat. Toxicol. 140-141 , 220-8, (2013)

The assessments of pesticide toxicity on nontarget organisms have largely been focused on the determination of median lethal concentration (LC50) values using single/laboratory species. Although usefu...

Fast agitated directly suspended droplet microextraction technique for the rapid analysis of eighteen organophosphorus pesticides in human blood.

J. Chromatogr. A. 1377 , 27-34, (2015)

A new sample preparation technique named as fast agitated directly suspended droplet microextraction (FA-DSDME) was proposed as an improved version of directly suspended droplet microextraction (DSDME...

Development of a more specific and accurate multiple reaction monitoring method based on GC-EI/MS/MS for simultaneously monitoring and determining 34 kinds of pesticides in Qianjinzhidai pills.

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A rapid and accurate multi-residue method was developed for simultaneously monitoring and determining 34 kinds of pesticides by GC-EI/MS/MS, successfully applied in Qianjinzhidai pills. Precision, rep...

 Synonyms

faat
Phosphorodithioic Acid S-[(5-Methoxy-2-oxo-1,3,4-thiadiazol-3(2H)-yl)methyl]O,O-Dimethyl Ester
Phosphorodithioic acid, S-[(5-methoxy-2-oxo-1,3,4-thiadiazol-3(2H)-yl)methyl] O,O-dimethyl ester
S-((5-methoxy-2-oxo-1,3,4-thiadiazol-3(2H)-yl)methyl) O,O-dimethyl phosphorodithioate
Dithiophosphoric Acid O,O'-Dimethyl-S-[(2-methoxy-1,3,4-thiadiazol-5(4H)-on-4-yl)methyl] Ester
Geigy GS 13005
S-[(5-Methoxy-2-oxo-1,3,4-thiadiazol-3(2H)-yl)methyl] O,O-dimethyl phosphorodithioate
sphat
NC2964
oms844
O,O'-Dimethyl-S-[(2-methoxy-1,3,4-thiadiazole-5(4H)-one-4-yl)methyl] Dithiophosphate
S-2,3-dihydro-5-methoxy-2-oxo-1,3,4-thiadiazol-3-ylmethyl O,O-dimethyl phosphorodithioate
3-dimethoxyphosphinothioylthiomethyl-5-methoxy-1,3,4-thiadiazol-2(3H)-one
Methadithion
dmtp
Phosphorodithioic Acid O,O-Dimethyl Ester S-Ester with 4-(Mercaptomethyl)-2-methoxy-D2-1,3,4-thiadiazolin-5-one
Somonil
O,O-dimethyl S-(2,3-dihydro-5-methoxy-2-oxo-1,3,4-thiadiazol-3-ylmethyl)phosphorodithioate
S-[(5-Methoxy-2-oxo-1,3,4-thiadiazol-3(2H)-yl)methyl]-O,O-dimethyldithiophosphat
Dithiophosphoric acid O,O'-dimethyl-S-[(5-methoxy-1,3,4-thiadiazol-2(3H)-one-3-yl)methyl] ester
hionate
MFCD00055286
Methidathion
T5NNVSJ B1SPS&O1&O1 EO1
EINECS 213-449-4
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