Erianin

Modify Date: 2025-08-21 17:55:46

Use of Erianin

Erianin, often used as an antipyretic and analgesic agent, could inhibit IDO-induced tumor angiogenesis.

Name	2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]phenol
Synonym	More Synonyms

Description	Erianin, often used as an antipyretic and analgesic agent, could inhibit IDO-induced tumor angiogenesis.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer Research Areas >> Neurological Disease Natural Products >> Others
In Vitro	Erianin is often used as antipyretic and analgesic agent. Erianin belongs to bibenzyl derivatives in structure, with the activity of anti-virus, anti-bacterial, as well as anti-benign prostatic hyperplasia. Erianin has obvious damage on 2LL-IDO cells, Erianin basically has no cytotoxicity on human normal liver cell line L02, and cell viability is maintained at around 85%[1]. Erianin inhibits the growth of HeLa cells and induces apoptosis in a dose‑ and time‑dependent manner, inducing cell cycle arrest at the G2/M stage. Erianin treatment also increases the expression of Bax and caspase‑3, but decreases levels of Bcl‑2 and phosphorylated‑ERK1/2[2].
References	[1]. Su C, et al. Erianin inhibits indoleamine 2, 3-dioxygenase -induced tumor angiogenesis. Biomed Pharmacother. 2017 Apr;88:521-528. [2]. Li M, et al. Erianin inhibits human cervical cancer cell through regulation of tumor protein p53 via the extracellular signal-regulated kinase signaling pathway. Oncol Lett. 2018 Oct;16(4):5006-5012.

Density	1.1±0.1 g/cm3
Boiling Point	439.1±40.0 °C at 760 mmHg
Molecular Formula	C₁₈H₂₂O₅
Molecular Weight	318.364
Flash Point	219.4±27.3 °C
Exact Mass	318.146729
PSA	57.15000
LogP	3.11
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.554
InChIKey	UXDFUVFNIAJEGM-UHFFFAOYSA-N
SMILES	COc1ccc(CCc2cc(OC)c(OC)c(OC)c2)cc1O

Precursor 7
CAS#:117048-62-1 2-methoxy-5-[2-... CAS#:3840-31-1 (3,4,5-Trimetho... CAS#:80192-89-8 3,4,5-trimethox... CAS#:847063-26-7 3-tert-butyldim...
CAS#:86-81-7 3,4,5-Trimethox... CAS#:121042-94-2 [3-[(tert-butyl... CAS#:61240-20-8 Triphenyl(3,4,5...
DownStream 0

Name: Inhibition of bovine tubulin polymerization
Source: ChEMBL
Target: Tubulin beta-2B chain
External Id: CHEMBL873906

Name: Antitumor activity against human HCCLM3 cells xenografted in NCR-nu/nu mouse assessed...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5047585

Name: Induction of apoptosis in human HCCLM3 cells assessed as nuclear condensation at 20 n...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5047584

Name: Antiinvasive activity against human HCCLM3 cells assessed as reduction in cell invasi...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5047583

Name: Induction of apoptosis in human HCCLM3 cells assessed as cell shrinkage at 20 nM incu...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5047582

Name: Half life in Beagle dog at 30 mg/kg, iv measured for 8 to 12 hrs by LC-MS/MS analysis
Source: ChEMBL
Target: N/A
External Id: CHEMBL5543419

Name: Half life in rat at 25 mg/kg, iv
Source: ChEMBL
Target: N/A
External Id: CHEMBL5543420

Name: Half life in rat at 50 mg/kg, iv
Source: ChEMBL
Target: N/A
External Id: CHEMBL5543421

Name: Half life in rat at 100 mg/kg, iv
Source: ChEMBL
Target: N/A
External Id: CHEMBL5543422

Name: Elimination half life in rat at 2 mg/kg, iv
Source: ChEMBL
Target: N/A
External Id: CHEMBL5543423

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Dihydrocombretatastin A-4

Erianin

2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)-ethyl]-phenol

5-(3,4,5-trimethoxyphenethyl)-2-methoxyphenol

2-Methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]phenol

(E)-2-methoxy-5-(3,4,5-trimethoxyphenylethyl)phenol

3-hydroxy-3',4',4,5'-tetramethoxybibenzyl

2-Methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]benzolol

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Price: ￥660/10 mM * 1 mL in DMSO

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