NVP-QAV-572

Modify Date: 2024-01-11 12:38:23

NVP-QAV-572 Structure
NVP-QAV-572 structure
Common Name NVP-QAV-572
CAS Number 957209-68-6 Molecular Weight 471.50500
Density 1.59±0.1 g/cm3 (20 °C, 760 mmHg) Boiling Point N/A
Molecular Formula C17H19F2N7O3S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of NVP-QAV-572


NVP-QAV-572 is a PI3K inhibitor extracted from patent US7998990B2, Compound Example 8, has an IC50 of 10 nM.

 Names

Name Urea, N-[2-[2-(2-fluoroethyl)-2H-tetrazol-5-yl]ethyl]-N'-[5-[3-fluoro-4-(methylsulfonyl)phenyl]-4-methyl-2-thiazolyl]
Synonym More Synonyms

 NVP-QAV-572 Biological Activity

Description NVP-QAV-572 is a PI3K inhibitor extracted from patent US7998990B2, Compound Example 8, has an IC50 of 10 nM.
Related Catalog
Target

PI3K:10 nM (IC50)

In Vitro NVP-QAV-572 (Example 8) is useful in the treatment of conditions which are mediated by the activation of the Pi3 kinase enzymes, particularly inflammatory or allergic conditions[1].
References

[1]. Emma Budd, et al. 5-phenyl-thiazol-2-yl-urea derivatives and use as PI3 kinase inhibitors. US 7998990 B2.

 Chemical & Physical Properties

Density 1.59±0.1 g/cm3 (20 °C, 760 mmHg)
Molecular Formula C17H19F2N7O3S2
Molecular Weight 471.50500
Exact Mass 471.09600
PSA 168.38000
LogP 3.52600
Storage condition 2-8℃

 Synonyms

nvp-qav-572
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