247016-69-9

247016-69-9 structure

Name: NVP DPP 728
Chemical Name: 6-[2-[[2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl]amino]ethylamino]pyridine-3-carbonitrile,dihydrochloride
CAS Number: 247016-69-9
Molecular Formula: C₁₅H₁₈N₆O
Molecular Weight: 298.34
Catalog: Signaling Pathways Metabolic Enzyme/Protease Dipeptidyl Peptidase
Create Date: 2017-12-17 06:40:51
Modify Date: 2024-01-01 20:24:12
NVP-DPP728 is a potent, reversible and nitrile-dependent dipeptidyl peptidase IV (DPP-IV) inhibitor. NVP-DPP728 can inhibit human DPP-IV amidolytic activity with a Ki of 11 nM. NVP-DPP728 inhibits degradation of glucagon-like peptide-1 (GLP-1) and thereby potentiates insulin release in response to glucose intake. NVP-DPP728 can be used for researching diabetes[1].

Name	6-[2-[[2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl]amino]ethylamino]pyridine-3-carbonitrile,dihydrochloride
Synonyms	3-Pyridinecarbonitrile, 6-[[2-[[2-[(2S)-2-cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino]-, hydrochloride (1:2) 6-{[2-({2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl}amino)ethyl]amino}nicotinonitrile dihydrochloride 6-{[2-({2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl}amino)ethyl]amino}nicotinonitrile dihydrochloride nvp dpp 728 dihydrochloride

Description	NVP-DPP728 is a potent, reversible and nitrile-dependent dipeptidyl peptidase IV (DPP-IV) inhibitor. NVP-DPP728 can inhibit human DPP-IV amidolytic activity with a Ki of 11 nM. NVP-DPP728 inhibits degradation of glucagon-like peptide-1 (GLP-1) and thereby potentiates insulin release in response to glucose intake. NVP-DPP728 can be used for researching diabetes[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Dipeptidyl Peptidase Research Areas >> Metabolic Disease
Target	Ki: 11 nM (DPP-IV)[1]
References	[1]. Hughes TE, et al. NVP-DPP728 (1-[[[2-[(5-cyanopyridin-2-yl)amino]ethyl]amino]acetyl]-2-cyano-(S)- pyrrolidine), a slow-binding inhibitor of dipeptidyl peptidase IV. Biochemistry. 1999;38(36):11597-11603.

Molecular Formula	C₁₅H₁₈N₆O
Molecular Weight	298.34
Exact Mass	370.107574
PSA	104.84000
LogP	2.47516

207557-35-5

202460-48-8

~32%

247016-69-9

Literature: Villhauer, Edwin B.; Brinkman, John A.; Naderi, Goli B.; Dunning, Beth E.; Mangold, Bonnie L.; Mone, Manisha D.; Russell, Mary E.; Weldon, Stephen C.; Hughes, Thomas E. Journal of Medicinal Chemistry, 2002 , vol. 45, # 12 p. 2362 - 2365

214398-99-9

247016-69-9

Literature: Villhauer, Edwin B.; Brinkman, John A.; Naderi, Goli B.; Burkey, Bryan F.; Dunning, Beth E.; Prasad, Kapa; Mangold, Bonnie L.; Russell, Mary E.; Hughes, Thomas E. Journal of Medicinal Chemistry, 2003 , vol. 46, # 13 p. 2774 - 2789

7531-52-4

247016-69-9

207557-33-3

247016-69-9

Literature: Willand, Nicolas; Joossens, Jurgen; Gesquiere, Jean-Claude; Tartar, Andre L; Evans, D.Michael; Roe, Michael B Tetrahedron, 2002 , vol. 58, # 28 p. 5741 - 5746

477290-51-0

247016-69-9

Literature: Willand, Nicolas; Joossens, Jurgen; Gesquiere, Jean-Claude; Tartar, Andre L; Evans, D.Michael; Roe, Michael B Tetrahedron, 2002 , vol. 58, # 28 p. 5741 - 5746

33252-28-7

247016-69-9

Precursor 6
207557-35-5 202460-48-8 214398-99-9 7531-52-4
207557-33-3 33252-28-7
DownStream 0

247016-69-9	207556-62-5
459836-30-7	1133206-74-2
1263373-43-8	2320258-95-3
2291360-73-9	475488-23-4
1313363-54-0	1313367-56-4
1158522-08-7	940364-43-2
134104-43-1	179554-67-7
131615-57-1	1213612-07-7
6906-52-1	1087639-32-4
930439-75-1	1018584-77-4