AGN 196996

Modify Date: 2024-01-05 17:07:19

AGN 196996 structure	Common Name	AGN 196996
	CAS Number	958295-17-5	Molecular Weight	482.32300
	Density	1.453±0.06 g/cm3 (20 °C, 760 mmHg)	Boiling Point	619.8±55.0 °C (760 mmHg)
	Molecular Formula	C₂₄H₂₀BrNO₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of AGN 196996

AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM).IC50 value: 2 nM(Ki)Target: RARα antagonistAGN 196996 shows no activity in transactivation assays, but instead block the gene transcriptional activity induced by ATRA and other RAR agonists.

Name	Benzoic acid, 4-[[3-bromo-4-ethoxy-5-(4-methylbenzoyl)benzoyl]amino]
Synonym	More Synonyms

Description	AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM).IC50 value: 2 nM(Ki)Target: RARα antagonistAGN 196996 shows no activity in transactivation assays, but instead block the gene transcriptional activity induced by ATRA and other RAR agonists.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR Research Areas >> Cancer
References	[1]. Hammond LA, et al. Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells. Br J Cancer. 2001 Aug 3;85(3):453-62. [2]. Keedwell RG, et al. An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium. Br J Cancer. 2004 Aug 2;91(3):580-8.

Description

Related Catalog

Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR

Research Areas >> Cancer

References

[1]. Hammond LA, et al. Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells. Br J Cancer. 2001 Aug 3;85(3):453-62.

[2]. Keedwell RG, et al. An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium. Br J Cancer. 2004 Aug 2;91(3):580-8.

Density	1.453±0.06 g/cm3 (20 °C, 760 mmHg)
Boiling Point	619.8±55.0 °C (760 mmHg)
Molecular Formula	C₂₄H₂₀BrNO₅
Molecular Weight	482.32300
Exact Mass	481.05200
PSA	92.70000
LogP	5.41070
Storage condition	2-8℃

AGN 196996

AGN 196996

Use of AGN 196996

Names

AGN 196996 Biological Activity

Chemical & Physical Properties

Synonyms