Plocabulin
Modify Date: 2025-08-23 13:08:14
Plocabulin structure
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Common Name | Plocabulin | ||
|---|---|---|---|---|
| CAS Number | 960210-99-5 | Molecular Weight | 571.705 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 862.5±65.0 °C at 760 mmHg | |
| Molecular Formula | C31H45N3O7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 475.4±34.3 °C | |
Use of PlocabulinPlocabulin (PM060184) is a novel tubulin-binding agent binding to αβ-tubulin dimer with nanomolar affinity, inhibits a panel of 23 tumor cell lines with GI50 of 20 pM-5 nM; inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells; also shows antifungal activity virtually abolishing growth of the filamentous fungus Aspergillus nidulans. |
| Name | plocabulin |
|---|---|
| Synonym | More Synonyms |
| Description | Plocabulin (PM060184) is a novel tubulin-binding agent binding to αβ-tubulin dimer with nanomolar affinity, inhibits a panel of 23 tumor cell lines with GI50 of 20 pM-5 nM; inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells; also shows antifungal activity virtually abolishing growth of the filamentous fungus Aspergillus nidulans. |
|---|---|
| References | References 1. Galmarini CM, et al. BMC Cancer. 2018 Feb 7;18(1):164. 2. Pantazopoulou A, et al. Sci Rep. 2018 Jun 5;8(1):8616. 3. Pera B, et al. ACS Chem Biol. 2013 Sep 20;8(9):2084-94. 4. Prota AE, et al. Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13817-21. View Related Products by Target Microtubule/Tubulin |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 862.5±65.0 °C at 760 mmHg |
| Molecular Formula | C31H45N3O7 |
| Molecular Weight | 571.705 |
| Flash Point | 475.4±34.3 °C |
| Exact Mass | 571.325745 |
| LogP | 3.35 |
| Vapour Pressure | 0.0±3.3 mmHg at 25°C |
| Index of Refraction | 1.546 |
| plocabulin |
| (1Z,4S,6Z)-1-[(N-{(2Z,4Z,6E,8S)-8-[(2S)-5-Methoxy-6-oxo-3,6-dihydro-2H-pyran-2-yl]-6-methyl-2,4,6-nonatrienoyl}-3-methyl-L-valyl)amino]-1,6-octadien-4-yl carbamate |
| 52Y8L60CR7 |
| PM-060184 |
| 2,4,6-Nonatrienamide, N-[(1S)-1-[[[(1Z,4S,6Z)-4-[(aminocarbonyl)oxy]-1,6-octadien-1-yl]amino]carbonyl]-2,2-dimethylpropyl]-8-[(2S)-3,6-dihydro-5-methoxy-6-oxo-2H-pyran-2-yl]-6-methyl-, (2Z,4Z,6E,8S)- |